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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. Franklin BS, et al. Among authors: busto p. Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952505 Free PMC article.
Role of Interferon-γ-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency.
Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Pawaria S, et al. Among authors: busto p. Arthritis Rheumatol. 2020 Feb;72(2):359-370. doi: 10.1002/art.41090. Epub 2019 Dec 29. Arthritis Rheumatol. 2020. PMID: 31464028 Free PMC article.
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