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Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Ibanez L, Bahena JA, Yang C, Dube U, Farias FHG, Budde JP, Bergmann K, Brenner-Webster C, Morris JC, Perrin RJ, Cairns NJ, O'Donnell J, Álvarez I, Diez-Fairen M, Aguilar M, Miller R, Davis AA, Pastor P, Kotzbauer P, Campbell MC, Perlmutter JS, Rhinn H, Harari O, Cruchaga C, Benitez BA. Ibanez L, et al. Among authors: cairns nj. Acta Neuropathol Commun. 2020 Nov 19;8(1):196. doi: 10.1186/s40478-020-01072-8. Acta Neuropathol Commun. 2020. PMID: 33213513 Free PMC article.
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.
Del-Aguila JL, Benitez BA, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Farias FHG, Fernández MV, Ibanez L, Jiang S, Perrin RJ, Cairns NJ, Morris JC, Harari O, Cruchaga C. Del-Aguila JL, et al. Among authors: cairns nj. Mol Neurodegener. 2019 May 8;14(1):18. doi: 10.1186/s13024-019-0319-3. Mol Neurodegener. 2019. PMID: 31068200 Free PMC article.
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.
Miller RL, Dhavale DD, O'Shea JY, Andruska KM, Liu J, Franklin EE, Buddhala C, Loftin SK, Cirrito JR, Perrin RJ, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT. Miller RL, et al. Among authors: cairns nj. Ann Clin Transl Neurol. 2022 Feb;9(2):106-121. doi: 10.1002/acn3.51482. Epub 2022 Jan 21. Ann Clin Transl Neurol. 2022. PMID: 35060360 Free PMC article.
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC; GERAD Consortium; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC); Goate AM. Cruchaga C, et al. Neuron. 2013 Apr 24;78(2):256-68. doi: 10.1016/j.neuron.2013.02.026. Epub 2013 Apr 4. Neuron. 2013. PMID: 23562540 Free PMC article.
Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease.
Buddhala C, Loftin SK, Kuley BM, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT. Buddhala C, et al. Among authors: cairns nj. Ann Clin Transl Neurol. 2015 Oct;2(10):949-59. doi: 10.1002/acn3.246. Epub 2015 Sep 12. Ann Clin Transl Neurol. 2015. PMID: 26478895 Free PMC article.
Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ; Dominantly Inherited Alzheimer Network (DIAN); Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O. Li Z, et al. Among authors: cairns nj. Genome Med. 2018 Jun 8;10(1):43. doi: 10.1186/s13073-018-0551-4. Genome Med. 2018. PMID: 29880032 Free PMC article.
Widespread distribution of tauopathy in preclinical Alzheimer's disease.
Schultz SA, Gordon BA, Mishra S, Su Y, Perrin RJ, Cairns NJ, Morris JC, Ances BM, Benzinger TLS. Schultz SA, et al. Among authors: cairns nj. Neurobiol Aging. 2018 Dec;72:177-185. doi: 10.1016/j.neurobiolaging.2018.08.022. Epub 2018 Sep 1. Neurobiol Aging. 2018. PMID: 30292840 Free PMC article.
Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, Xiong C, Bateman RJ, Ghetti B, Ringman JM, Chhatwal J, Masters CL, McLean C, Lashley T, Su Y, Koeppe R, Jack C, Klunk WE, Morris JC, Perrin RJ, Cairns NJ, Benzinger TLS. Chen CD, et al. Among authors: cairns nj. Acta Neuropathol. 2021 Oct;142(4):689-706. doi: 10.1007/s00401-021-02342-y. Epub 2021 Jul 28. Acta Neuropathol. 2021. PMID: 34319442 Free PMC article.
685 results