Carra S - Search Results

1

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.

Crippa V, Cicardi ME, Ramesh N, Seguin SJ, Ganassi M, Bigi I, Diacci C, Zelotti E, Baratashvili M, Gregory JM, Dobson CM, Cereda C, Pandey UB, Poletti A, Carra S. Crippa V, et al. Among authors: carra s. Hum Mol Genet. 2016 Sep 15;25(18):3908-3924. doi: 10.1093/hmg/ddw232. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466192 Free PMC article.

2

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

Carra S, Sivilotti M, Chávez Zobel AT, Lambert H, Landry J. Carra S, et al. Hum Mol Genet. 2005 Jun 15;14(12):1659-69. doi: 10.1093/hmg/ddi174. Epub 2005 May 6. Hum Mol Genet. 2005. PMID: 15879436

3

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

Carra S, Seguin SJ, Lambert H, Landry J. Carra S, et al. J Biol Chem. 2008 Jan 18;283(3):1437-1444. doi: 10.1074/jbc.M706304200. Epub 2007 Nov 15. J Biol Chem. 2008. PMID: 18006506 Free article.

4

HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.

Carra S, Seguin SJ, Landry J. Carra S, et al. Autophagy. 2008 Feb;4(2):237-9. doi: 10.4161/auto.5407. Epub 2007 Dec 11. Autophagy. 2008. PMID: 18094623 Review.

5

Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.

Fuchs M, Poirier DJ, Seguin SJ, Lambert H, Carra S, Charette SJ, Landry J. Fuchs M, et al. Among authors: carra s. Biochem J. 2009 Dec 14;425(1):245-55. doi: 10.1042/BJ20090907. Biochem J. 2009. PMID: 19845507

6

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A. Crippa V, et al. Among authors: carra s. Hum Mol Genet. 2010 Sep 1;19(17):3440-56. doi: 10.1093/hmg/ddq257. Epub 2010 Jun 22. Hum Mol Genet. 2010. PMID: 20570967 Free article.

7

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases.

Crippa V, Carra S, Rusmini P, Sau D, Bolzoni E, Bendotti C, De Biasi S, Poletti A. Crippa V, et al. Among authors: carra s. Autophagy. 2010 Oct;6(7):958-60. doi: 10.4161/auto.6.7.13042. Epub 2010 Oct 16. Autophagy. 2010. PMID: 20699640

8

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones.

Vos MJ, Zijlstra MP, Kanon B, van Waarde-Verhagen MA, Brunt ER, Oosterveld-Hut HM, Carra S, Sibon OC, Kampinga HH. Vos MJ, et al. Among authors: carra s. Hum Mol Genet. 2010 Dec 1;19(23):4677-93. doi: 10.1093/hmg/ddq398. Epub 2010 Sep 15. Hum Mol Genet. 2010. PMID: 20843828

9

Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

Carra S, Boncoraglio A, Kanon B, Brunsting JF, Minoia M, Rana A, Vos MJ, Seidel K, Sibon OC, Kampinga HH. Carra S, et al. J Biol Chem. 2010 Nov 26;285(48):37811-22. doi: 10.1074/jbc.M110.127498. Epub 2010 Sep 21. J Biol Chem. 2010. PMID: 20858900 Free PMC article.

In cells, HSPB8 cooperates with BAG3 to stimulate autophagy in an eIF2alpha-dependent manner and facilitates the clearance of aggregate-prone proteins (Carra, S., Seguin, S. J., Lambert, H., and Landry, J. (2008) J. Biol. Chem. 283, 1437-1444; Carra, …

In cells, HSPB8 cooperates with BAG3 to stimulate autophagy in an eIF2alpha-dependent manner and facilitates the clearance of aggregate-pron …

10

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases.

Seidel K, Vinet J, Dunnen WF, Brunt ER, Meister M, Boncoraglio A, Zijlstra MP, Boddeke HW, Rüb U, Kampinga HH, Carra S. Seidel K, et al. Among authors: carra s. Neuropathol Appl Neurobiol. 2012 Feb;38(1):39-53. doi: 10.1111/j.1365-2990.2011.01198.x. Neuropathol Appl Neurobiol. 2012. PMID: 21696420

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