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Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.
Spencer AG, Labonte ED, Rosenbaum DP, Plato CF, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Bell N, Tabora J, Joly KM, Navre M, Jacobs JW, Charmot D. Spencer AG, et al. Among authors: carreras cw. Sci Transl Med. 2014 Mar 12;6(227):227ra36. doi: 10.1126/scitranslmed.3007790. Sci Transl Med. 2014. PMID: 24622516 Clinical Trial.
Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.
Labonté ED, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Dy E, Black D, Zhong Z, Langsetmo I, Spencer AG, Bell N, Deshpande D, Navre M, Lewis JG, Jacobs JW, Charmot D. Labonté ED, et al. Among authors: carreras cw. J Am Soc Nephrol. 2015 May;26(5):1138-49. doi: 10.1681/ASN.2014030317. Epub 2014 Nov 17. J Am Soc Nephrol. 2015. PMID: 25404658 Free PMC article.
Potent cytotoxic C-11 modified geldanamycin analogues.
Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y. Tian ZQ, et al. Among authors: carreras cw. J Med Chem. 2009 May 28;52(10):3265-73. doi: 10.1021/jm900098v. J Med Chem. 2009. PMID: 19405528
9-Dihydroerythromycins as non-antibiotic motilin receptor agonists.
Liu Y, Li Y, Chen Y, Zheng H, Claypool M, Myles DC, Carreras CW. Liu Y, et al. Among authors: carreras cw. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5658-61. doi: 10.1016/j.bmcl.2010.08.030. Epub 2010 Aug 9. Bioorg Med Chem Lett. 2010. PMID: 20801039
35 results