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Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Daigle JG, et al. Among authors: casci i. Acta Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016 Jan 4. Acta Neuropathol. 2016. PMID: 26728149 Free PMC article.
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.
Daigle JG, Lanson NA Jr, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB. Daigle JG, et al. Among authors: casci i. Hum Mol Genet. 2013 Mar 15;22(6):1193-205. doi: 10.1093/hmg/dds526. Epub 2012 Dec 20. Hum Mol Genet. 2013. PMID: 23257289 Free PMC article.
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB. Casci I, et al. Nat Commun. 2019 Dec 6;10(1):5583. doi: 10.1038/s41467-019-13383-z. Nat Commun. 2019. PMID: 31811140 Free PMC article.
A fruitful endeavor: modeling ALS in the fruit fly.
Casci I, Pandey UB. Casci I, et al. Brain Res. 2015 May 14;1607:47-74. doi: 10.1016/j.brainres.2014.09.064. Epub 2014 Oct 5. Brain Res. 2015. PMID: 25289585 Free PMC article. Review.
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL. Marrone L, et al. Among authors: casci i. Stem Cell Reports. 2018 Feb 13;10(2):375-389. doi: 10.1016/j.stemcr.2017.12.018. Epub 2018 Jan 18. Stem Cell Reports. 2018. PMID: 29358088 Free PMC article.
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Scaramuzzino C, Casci I, Parodi S, Lievens PMJ, Polanco MJ, Milioto C, Chivet M, Monaghan J, Mishra A, Badders N, Aggarwal T, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB, Pennuto M. Scaramuzzino C, et al. Among authors: casci i. Neuron. 2015 Jan 7;85(1):88-100. doi: 10.1016/j.neuron.2014.12.031. Neuron. 2015. PMID: 25569348 Free PMC article.