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Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.
Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. Coyne AN, et al. Among authors: cassel ja. Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18. Hum Mol Genet. 2015. PMID: 26385636 Free PMC article.
Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Messick TE, Smith GR, Soldan SS, McDonnell ME, Deakyne JS, Malecka KA, Tolvinski L, van den Heuvel APJ, Gu BW, Cassel JA, Tran DH, Wassermann BR, Zhang Y, Velvadapu V, Zartler ER, Busson P, Reitz AB, Lieberman PM. Messick TE, et al. Among authors: cassel ja. Sci Transl Med. 2019 Mar 6;11(482):eaau5612. doi: 10.1126/scitranslmed.aau5612. Sci Transl Med. 2019. PMID: 30842315 Free PMC article.
Novel malonamide derivatives as potent kappa opioid receptor agonists.
Chu GH, Gu M, Cassel JA, Belanger S, Graczyk TM, DeHaven RN, Conway-James N, Koblish M, Little PJ, DeHaven-Hudkins DL, Dolle RE. Chu GH, et al. Among authors: cassel ja. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1951-5. doi: 10.1016/j.bmcl.2007.01.053. Epub 2007 Jan 25. Bioorg Med Chem Lett. 2007. PMID: 17307360
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. Among authors: cassel ja. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. doi: 10.1016/j.bmcl.2007.10.073. Epub 2007 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18024030
Arylacetamides as peripherally restricted kappa opioid receptor agonists.
Kumar V, Marella MA, Cortes-Burgos L, Chang AC, Cassel JA, Daubert JD, DeHaven RN, DeHaven-Hudkins DL, Gottshall SL, Mansson E, Maycock AL. Kumar V, et al. Among authors: cassel ja. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2567-70. doi: 10.1016/s0960-894x(00)00519-9. Bioorg Med Chem Lett. 2000. PMID: 11086731
61 results