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N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
Yang GX, Chang LL, Truong Q, Doherty GA, Magriotis PA, de Laszlo SE, Li B, MacCoss M, Kidambi U, Egger LA, McCauley E, Van Riper G, Mumford RA, Schmidt JA, Hagmann WK. Yang GX, et al. Among authors: chang ll. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1497-500. doi: 10.1016/s0960-894x(02)00210-x. Bioorg Med Chem Lett. 2002. PMID: 12031328
Highly constrained bicyclic VLA-4 antagonists.
Chang LL, Truong Q, Doss GA, MacCoss M, Lyons K, McCauley E, Mumford R, Forrest G, Vincent S, Schmidt JA, Hagmann WK. Chang LL, et al. Bioorg Med Chem Lett. 2007 Feb 1;17(3):597-601. doi: 10.1016/j.bmcl.2006.11.011. Epub 2006 Nov 7. Bioorg Med Chem Lett. 2007. PMID: 17118652
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Armstrong HE, Galka A, Lin LS, Lanza TJ Jr, Jewell JP, Shah SK, Guthikonda R, Truong Q, Chang LL, Quaker G, Colandrea VJ, Tong X, Wang J, Xu S, Fong TM, Shen CP, Lao J, Chen J, Shearman LP, Stribling DS, Rosko K, Strack A, Ha S, Van der Ploeg L, Goulet MT, Hagmann WK. Armstrong HE, et al. Among authors: chang ll. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2184-7. doi: 10.1016/j.bmcl.2007.01.087. Epub 2007 Feb 2. Bioorg Med Chem Lett. 2007. PMID: 17293109
Pyrroles and other heterocycles as inhibitors of p38 kinase.
de Laszlo SE, Visco D, Agarwal L, Chang L, Chin J, Croft G, Forsyth A, Fletcher D, Frantz B, Hacker C, Hanlon W, Harper C, Kostura M, Li B, Luell S, MacCoss M, Mantlo N, O'Neill EA, Orevillo C, Pang M, Parsons J, Rolando A, Sahly Y, Sidler K, O'Keefe SJ, et al. de Laszlo SE, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. doi: 10.1016/s0960-894x(98)00495-8. Bioorg Med Chem Lett. 1998. PMID: 9873604
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Chu L, Armstrong HM, Chang LL, Cheng AF, Colwell L, Cui J, Evans J, Galka A, Goulet MT, Hayes N, Lo J, Menke J, Ok HO, Ondeyka DL, Patel M, Quaker GM, Sings H, Witkin SL, Zhao A, Ujjainwalla F. Chu L, et al. Among authors: chang ll. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4133-8. doi: 10.1016/j.bmcl.2012.04.064. Epub 2012 Apr 20. Bioorg Med Chem Lett. 2012. PMID: 22578458
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
Biftu T, Feng D, Ponpipom M, Girotra N, Liang GB, Qian X, Bugianesi R, Simeone J, Chang L, Gurnett A, Liberator P, Dulski P, Leavitt PS, Crumley T, Misura A, Murphy T, Rattray S, Samaras S, Tamas T, Mathew J, Brown C, Thompson D, Schmatz D, Fisher M, Wyvratt M. Biftu T, et al. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3296-301. doi: 10.1016/j.bmcl.2005.04.060. Bioorg Med Chem Lett. 2005. PMID: 15922595
296 results