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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S. Baranger K, et al. Among authors: checler f. Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23. Cell Mol Life Sci. 2016. PMID: 26202697 Free PMC article.
The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.
Cissé M, Duplan E, Guillot-Sestier MV, Rumigny J, Bauer C, Pagès G, Orzechowski HD, Slack BE, Checler F, Vincent B. Cissé M, et al. Among authors: checler f. J Biol Chem. 2011 Aug 19;286(33):29192-29206. doi: 10.1074/jbc.M110.208249. Epub 2011 May 17. J Biol Chem. 2011. PMID: 21586567 Free PMC article.
The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St-George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F. Lauritzen I, et al. Among authors: checler f. J Neurosci. 2012 Nov 14;32(46):16243-1655a. doi: 10.1523/JNEUROSCI.2775-12.2012. J Neurosci. 2012. PMID: 23152608 Free PMC article.
Study on Aβ34 biology and detection in transgenic mice brains.
Caillava C, Ranaldi S, Lauritzen I, Bauer C, Fareh J, Abraham JD, Checler F. Caillava C, et al. Among authors: checler f. Neurobiol Aging. 2014 Jul;35(7):1570-81. doi: 10.1016/j.neurobiolaging.2014.01.011. Epub 2014 Jan 11. Neurobiol Aging. 2014. PMID: 24495834
275 results