Chen D - Search Results

1

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.

Yang H, Chen D, Cui QC, Yuan X, Dou QP. Yang H, et al. Among authors: chen d. Cancer Res. 2006 May 1;66(9):4758-65. doi: 10.1158/0008-5472.CAN-05-4529. Cancer Res. 2006. PMID: 16651429

2

Molecular study on copper-mediated tumor proteasome inhibition and cell death.

Xiao Y, Chen DI, Zhang X, Cui Q, Fan Y, Bi C, Dou QP. Xiao Y, et al. Among authors: chen di. Int J Oncol. 2010 Jul;37(1):81-87. doi: 10.3892/ijo_00000655. Int J Oncol. 2010. PMID: 20514399 Free PMC article.

3

Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.

Yang H, Landis-Piwowar KR, Chen D, Milacic V, Dou QP. Yang H, et al. Among authors: chen d. Curr Protein Pept Sci. 2008 Jun;9(3):227-39. doi: 10.2174/138920308784533998. Curr Protein Pept Sci. 2008. PMID: 18537678 Free PMC article. Review.

4

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives.

Chen D, Frezza M, Schmitt S, Kanwar J, Dou QP. Chen D, et al. Curr Cancer Drug Targets. 2011 Mar;11(3):239-53. doi: 10.2174/156800911794519752. Curr Cancer Drug Targets. 2011. PMID: 21247388 Free PMC article. Review.

5

Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death.

Chen MS, Chen D, Dou QP. Chen MS, et al. Among authors: chen d. In Vivo. 2004 Jan-Feb;18(1):73-80. In Vivo. 2004. PMID: 15011755 Free article.

6

Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis.

Chen D, Peng F, Cui QC, Daniel KG, Orlu S, Liu J, Dou QP. Chen D, et al. Front Biosci. 2005 Sep 1;10:2932-9. doi: 10.2741/1749. Front Biosci. 2005. PMID: 15970547 Review.

Most recently, we have found that when complexed with copper, the known antioxidant pyrrolidine dithiocarbamate (PDTC) forms a potent proteasome inhibitor in human breast cancer, but not normal cells (Daniel, Chen, et al., submitted). In the current study, we investigate w …

Most recently, we have found that when complexed with copper, the known antioxidant pyrrolidine dithiocarbamate (PDTC) forms a potent protea …

7

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.

Daniel KG, Chen D, Orlu S, Cui QC, Miller FR, Dou QP. Daniel KG, et al. Among authors: chen d. Breast Cancer Res. 2005;7(6):R897-908. doi: 10.1186/bcr1322. Epub 2005 Sep 20. Breast Cancer Res. 2005. PMID: 16280039 Free PMC article.

8

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.

Chen D, Cui QC, Yang H, Dou QP. Chen D, et al. Cancer Res. 2006 Nov 1;66(21):10425-33. doi: 10.1158/0008-5472.CAN-06-2126. Cancer Res. 2006. PMID: 17079463

9

A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.

Milacic V, Chen D, Ronconi L, Landis-Piwowar KR, Fregona D, Dou QP. Milacic V, et al. Among authors: chen d. Cancer Res. 2006 Nov 1;66(21):10478-86. doi: 10.1158/0008-5472.CAN-06-3017. Cancer Res. 2006. PMID: 17079469

10

Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.

Adsule S, Barve V, Chen D, Ahmed F, Dou QP, Padhye S, Sarkar FH. Adsule S, et al. Among authors: chen d. J Med Chem. 2006 Nov 30;49(24):7242-6. doi: 10.1021/jm060712l. J Med Chem. 2006. PMID: 17125278

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