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Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
Corboz MR, Li Z, Malinin V, Plaunt AJ, Konicek DM, Leifer FG, Chen KJ, Laurent CE, Yin H, Biernat MC, Salvail D, Zhuang J, Xu F, Curran A, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: chen kj. J Pharmacol Exp Ther. 2017 Dec;363(3):348-357. doi: 10.1124/jpet.117.242099. Epub 2017 Sep 13. J Pharmacol Exp Ther. 2017. PMID: 28904003
Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Corboz MR, Salvail W, Gagnon S, LaSala D, Laurent CE, Salvail D, Chen KJ, Cipolla D, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: chen kj. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106486. doi: 10.1016/j.prostaglandins.2020.106486. Epub 2020 Oct 1. Prostaglandins Other Lipid Mediat. 2021. PMID: 33011365 Free article.
Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Plaunt AJ, Rose SJ, Kang JY, Chen KJ, LaSala D, Heckler RP, Dorfman A, Smith BT, Chun D, Viramontes V, Macaluso A, Li Z, Zhou Y, Mark L, Basso J, Leifer FG, Corboz MR, Chapman RW, Cipolla D, Perkins WR, Malinin VS, Konicek DM. Plaunt AJ, et al. Among authors: chen kj. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0031621. doi: 10.1128/AAC.00316-21. Epub 2021 Jun 17. Antimicrob Agents Chemother. 2021. PMID: 33941518 Free PMC article.
Recent advances in prodrug-based nanoparticle therapeutics.
Chen KJ, Plaunt AJ, Leifer FG, Kang JY, Cipolla D. Chen KJ, et al. Eur J Pharm Biopharm. 2021 Aug;165:219-243. doi: 10.1016/j.ejpb.2021.04.025. Epub 2021 May 9. Eur J Pharm Biopharm. 2021. PMID: 33979661 Free article. Review.
Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Plaunt AJ, Rose SJ, Kang JY, Chen KJ, LaSala D, Heckler RP, Dorfman A, Smith BT, Chun D, Viramontes V, Macaluso A, Li Z, Zhou Y, Mark L, Basso J, Leifer FG, Corboz MR, Chapman RW, Cipolla D, Perkins WR, Malinin VS, Konicek DM. Plaunt AJ, et al. Among authors: chen kj. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0125622. doi: 10.1128/aac.01256-22. Epub 2022 Oct 12. Antimicrob Agents Chemother. 2022. PMID: 36222535 Free PMC article. No abstract available.
The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Basso J, Chen KJ, Zhou Y, Mark L, LaSala D, Dorfman A, Atalla M, Chun D, Viramontes V, Chang C, Leifer F, McDonald PP, Cipolla DC. Basso J, et al. Among authors: chen kj. Front Pharmacol. 2023 Jul 19;14:1208780. doi: 10.3389/fphar.2023.1208780. eCollection 2023. Front Pharmacol. 2023. PMID: 37538173 Free PMC article.
1,077 results