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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington TL, Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP; Understanding Society Scientific Group; Campbell A, Porteous DJ, Jarvelin MR, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson JF, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, Kähönen M, Surakka I, Vitart V, Hayward C, Lehtimäki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Bossé Y, Joubert P, van den Berge M, Brandsma CA, Paré PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL; Geisinger-Regeneron DiscovEHR Collaboration; Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJ, Walters RG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho M… See abstract for full author list ➔ Wain LV, et al. Among authors: chen z. Nat Genet. 2017 Mar;49(3):416-425. doi: 10.1038/ng.3787. Epub 2017 Feb 6. Nat Genet. 2017. PMID: 28166213 Free PMC article.
Exhaled carbon monoxide and its associations with smoking, indoor household air pollution and chronic respiratory diseases among 512,000 Chinese adults.
Zhang Q, Li L, Smith M, Guo Y, Whitlock G, Bian Z, Kurmi O, Collins R, Chen J, Lv S, Pang Z, Chen C, Chen N, Xiong Y, Peto R, Chen Z; China Kadoorie Biobank study collaboration. Zhang Q, et al. Among authors: chen j, chen z, chen n, chen c. Int J Epidemiol. 2013 Oct;42(5):1464-75. doi: 10.1093/ije/dyt158. Epub 2013 Sep 20. Int J Epidemiol. 2013. PMID: 24057999 Free PMC article.
COPD and its association with smoking in the Mainland China: a cross-sectional analysis of 0.5 million men and women from ten diverse areas.
Kurmi OP, Li L, Wang J, Millwood IY, Chen J, Collins R, Guo Y, Bian Z, Li J, Chen B, Xie K, Jia W, Gao Y, Peto R, Chen Z. Kurmi OP, et al. Among authors: chen j, chen z, chen b. Int J Chron Obstruct Pulmon Dis. 2015 Mar 20;10:655-65. doi: 10.2147/COPD.S75454. eCollection 2015. Int J Chron Obstruct Pulmon Dis. 2015. PMID: 25848242 Free PMC article.
Gender-specific association between tobacco smoking and central obesity among 0.5 million Chinese people: the China Kadoorie Biobank Study.
Lv J, Chen W, Sun D, Li S, Millwood IY, Smith M, Guo Y, Bian Z, Yu C, Zhou H, Tan Y, Chen J, Chen Z, Li L; China Kadoorie Biobank collaborative group. Lv J, et al. Among authors: chen j, chen z, chen w. PLoS One. 2015 Apr 21;10(4):e0124586. doi: 10.1371/journal.pone.0124586. eCollection 2015. PLoS One. 2015. PMID: 25897789 Free PMC article.
Validity of COPD diagnoses reported through nationwide health insurance systems in the People's Republic of China.
Kurmi OP, Vaucher J, Xiao D, Holmes MV, Guo Y, Davis KJ, Wang C, Qin H, Turnbull I, Peng P, Bian Z, Clarke R, Li L, Chen Y, Chen Z. Kurmi OP, et al. Among authors: chen z, chen y. Int J Chron Obstruct Pulmon Dis. 2016 Mar 1;11:419-30. doi: 10.2147/COPD.S100736. eCollection 2016. Int J Chron Obstruct Pulmon Dis. 2016. PMID: 27042034 Free PMC article.
Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.
Gan W, Walters RG, Holmes MV, Bragg F, Millwood IY, Banasik K, Chen Y, Du H, Iona A, Mahajan A, Yang L, Bian Z, Guo Y, Clarke RJ, Li L, McCarthy MI, Chen Z; China Kadoorie Biobank Collaborative Group. Gan W, et al. Among authors: chen z, chen y. Diabetologia. 2016 Jul;59(7):1446-1457. doi: 10.1007/s00125-016-3920-9. Epub 2016 Apr 6. Diabetologia. 2016. PMID: 27053236 Free PMC article.
Parenthood and the risk of diabetes in men and women: a 7 year prospective study of 0.5 million individuals.
Peters SA, Yang L, Guo Y, Chen Y, Bian Z, Millwood IY, Bragg F, Zhou X, Ge P, Chen B, Gao Y, Li Y, Chen J, Li L, Woodward M, Chen Z; China Kadoorie Biobank Collaboration Group. Peters SA, et al. Among authors: chen j, chen z, chen b, chen y. Diabetologia. 2016 Aug;59(8):1675-82. doi: 10.1007/s00125-016-3980-x. Epub 2016 May 18. Diabetologia. 2016. PMID: 27193915 Free PMC article.
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.
Millwood IY, Bennett DA, Walters RG, Clarke R, Waterworth D, Johnson T, Chen Y, Yang L, Guo Y, Bian Z, Hacker A, Yeo A, Parish S, Hill MR, Chissoe S, Peto R, Cardon L, Collins R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group. Millwood IY, et al. Among authors: chen z, chen y. Int J Epidemiol. 2016 Oct;45(5):1588-1599. doi: 10.1093/ije/dyw087. Epub 2016 Jun 14. Int J Epidemiol. 2016. PMID: 27301456 Free PMC article.
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