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Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
Rothwell S, Cooper RG, Lundberg IE, Miller FW, Gregersen PK, Bowes J, Vencovsky J, Danko K, Limaye V, Selva-O'Callaghan A, Hanna MG, Machado PM, Pachman LM, Reed AM, Rider LG, Cobb J, Platt H, Molberg Ø, Benveniste O, Mathiesen P, Radstake T, Doria A, De Bleecker J, De Paepe B, Maurer B, Ollier WE, Padyukov L, O'Hanlon TP, Lee A, Amos CI, Gieger C, Meitinger T, Winkelmann J, Wedderburn LR, Chinoy H, Lamb JA; Myositis Genetics Consortium. Rothwell S, et al. Among authors: chinoy h. Ann Rheum Dis. 2016 Aug;75(8):1558-66. doi: 10.1136/annrheumdis-2015-208119. Epub 2015 Sep 11. Ann Rheum Dis. 2016. PMID: 26362759 Free PMC article.
In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype.
Chinoy H, Salway F, Fertig N, Shephard N, Tait BD, Thomson W, Isenberg DA, Oddis CV, Silman AJ, Ollier WE, Cooper RG; UK Adult Onset Myositis Immunogenetic Collaboration (AOMIC). Chinoy H, et al. Arthritis Res Ther. 2006;8(1):R13. doi: 10.1186/ar1862. Arthritis Res Ther. 2006. PMID: 16507114 Free PMC article.
Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies.
Chinoy H, Salway F, John S, Fertig N, Tait BD, Oddis CV, Ollier WE, Cooper RG; UK Adult Onset Myositis Immunogenetic Collaboration (AOMIC). Chinoy H, et al. Rheumatology (Oxford). 2007 Sep;46(9):1411-6. doi: 10.1093/rheumatology/kem145. Epub 2007 Jun 22. Rheumatology (Oxford). 2007. PMID: 17586554
HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap.
Wedderburn LR, McHugh NJ, Chinoy H, Cooper RG, Salway F, Ollier WE, McCann LJ, Varsani H, Dunphy J, North J, Davidson JE; Juvenile Dermatomyositis Research Group (JDRG). Wedderburn LR, et al. Among authors: chinoy h. Rheumatology (Oxford). 2007 Dec;46(12):1786-91. doi: 10.1093/rheumatology/kem265. Epub 2007 Nov 14. Rheumatology (Oxford). 2007. PMID: 18003662
241 results