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Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner.
Reddy SA, Shelar SB, Dang TM, Lee BN, Yang H, Ong SM, Ng HL, Chui WK, Wong SC, Chew EH. Reddy SA, et al. Among authors: chui wk. Int Immunopharmacol. 2015 Feb;24(2):440-450. doi: 10.1016/j.intimp.2014.12.037. Epub 2015 Jan 10. Int Immunopharmacol. 2015. PMID: 25585231
Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway.
Gan FF, Zhang R, Ng HL, Karuppasamy M, Seah W, Yeap WH, Ong SM, Hadadi E, Wong SC, Chui WK, Chew EH. Gan FF, et al. Among authors: chui wk. Food Chem Toxicol. 2018 Jun;116(Pt B):238-248. doi: 10.1016/j.fct.2018.04.003. Epub 2018 Apr 7. Food Chem Toxicol. 2018. PMID: 29630947
Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.
Gan FF, Kaminska KK, Yang H, Liew CY, Leow PC, So CL, Tu LN, Roy A, Yap CW, Kang TS, Chui WK, Chew EH. Gan FF, et al. Among authors: chui wk. Antioxid Redox Signal. 2013 Oct 10;19(11):1149-65. doi: 10.1089/ars.2012.4909. Epub 2013 Feb 28. Antioxid Redox Signal. 2013. PMID: 23311917 Free PMC article.
77 results