Clark RW - Search Results

1

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol.

Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ. Brousseau ME, et al. Among authors: clark rw. N Engl J Med. 2004 Apr 8;350(15):1505-15. doi: 10.1056/NEJMoa031766. N Engl J Med. 2004. PMID: 15071125 Free article. Clinical Trial.

2

Pharmacokinetic, pharmacodynamic, and safety profile of a new cholesteryl ester transfer protein inhibitor in healthy human subjects.

Wolk R, Chen D, Clark RW, Mancuso J, Barclay PL. Wolk R, et al. Among authors: clark rw. Clin Pharmacol Ther. 2009 Oct;86(4):430-7. doi: 10.1038/clpt.2009.120. Epub 2009 Jul 8. Clin Pharmacol Ther. 2009. PMID: 19587642 Clinical Trial.

3

Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib.

Clark RW, Sutfin TA, Ruggeri RB, Willauer AT, Sugarman ED, Magnus-Aryitey G, Cosgrove PG, Sand TM, Wester RT, Williams JA, Perlman ME, Bamberger MJ. Clark RW, et al. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7. doi: 10.1161/01.ATV.0000118278.21719.17. Epub 2004 Jan 22. Arterioscler Thromb Vasc Biol. 2004. PMID: 14739125 Clinical Trial.

4

Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action.

Clark RW, Ruggeri RB, Cunningham D, Bamberger MJ. Clark RW, et al. J Lipid Res. 2006 Mar;47(3):537-52. doi: 10.1194/jlr.M500349-JLR200. Epub 2005 Dec 2. J Lipid Res. 2006. PMID: 16326978 Free article.

5

Raising high-density lipoprotein with cholesteryl ester transfer protein inhibitors.

Clark RW. Clark RW. Curr Opin Pharmacol. 2006 Apr;6(2):162-8. doi: 10.1016/j.coph.2005.10.012. Epub 2006 Feb 17. Curr Opin Pharmacol. 2006. PMID: 16487747 Review.

6

Inhibition of cholesteryl ester transfer protein activity in hamsters alters HDL lipid composition.

Gaynor BJ, Sand T, Clark RW, Aiello RJ, Bamberger MJ, Moberly JB. Gaynor BJ, et al. Among authors: clark rw. Atherosclerosis. 1994 Sep 30;110(1):101-9. doi: 10.1016/0021-9150(94)90073-6. Atherosclerosis. 1994. PMID: 7857364

7

Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection.

Clark RW, Cunningham D, Cong Y, Subashi TA, Tkalcevic GT, Lloyd DB, Boyd JG, Chrunyk BA, Karam GA, Qiu X, Wang IK, Francone OL. Clark RW, et al. J Lipid Res. 2010 May;51(5):967-74. doi: 10.1194/jlr.M002295. Epub 2009 Oct 21. J Lipid Res. 2010. PMID: 19965592 Free PMC article.

8

Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.

Kalgutkar AS, Frederick KS, Hatch HL, Ambler CM, Perry DA, Garigipati RS, Chang GC, Lefker BA, Clark RW, Morehouse LA, Francone O, Hu X. Kalgutkar AS, et al. Among authors: clark rw. Xenobiotica. 2014 Jul;44(7):591-605. doi: 10.3109/00498254.2013.874611. Epub 2013 Dec 31. Xenobiotica. 2014. PMID: 24380613

9

Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.

Liu S, Mistry A, Reynolds JM, Lloyd DB, Griffor MC, Perry DA, Ruggeri RB, Clark RW, Qiu X. Liu S, et al. Among authors: clark rw. J Biol Chem. 2012 Oct 26;287(44):37321-9. doi: 10.1074/jbc.M112.380063. Epub 2012 Sep 7. J Biol Chem. 2012. PMID: 22961980 Free PMC article.

10

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.

Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP. Qiu X, et al. Among authors: clark rw. Nat Struct Mol Biol. 2007 Feb;14(2):106-13. doi: 10.1038/nsmb1197. Epub 2007 Jan 21. Nat Struct Mol Biol. 2007. PMID: 17237796

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