Coyne AN - Search Results

1

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. Coyne AN, et al. Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18. Hum Mol Genet. 2015. PMID: 26385636 Free PMC article.

2

Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.

Coyne AN, Siddegowda BB, Estes PS, Johannesmeyer J, Kovalik T, Daniel SG, Pearson A, Bowser R, Zarnescu DC. Coyne AN, et al. J Neurosci. 2014 Nov 26;34(48):15962-74. doi: 10.1523/JNEUROSCI.2526-14.2014. J Neurosci. 2014. PMID: 25429138 Free PMC article.

3

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.

Coyne AN, Zarnescu DC. Coyne AN, et al. PLoS Genet. 2016 Nov 17;12(11):e1006419. doi: 10.1371/journal.pgen.1006419. eCollection 2016 Nov. PLoS Genet. 2016. PMID: 27855157 Free PMC article. No abstract available.

4

Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.

Coyne AN, Zaepfel BL, Zarnescu DC. Coyne AN, et al. Front Cell Neurosci. 2017 Aug 17;11:243. doi: 10.3389/fncel.2017.00243. eCollection 2017. Front Cell Neurosci. 2017. PMID: 28860970 Free PMC article. Review.

5

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Coyne AN, et al. Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028. Cell Rep. 2017. PMID: 28978466 Free PMC article.

6

Endocytosis regulates TDP-43 toxicity and turnover.

Liu G, Coyne AN, Pei F, Vaughan S, Chaung M, Zarnescu DC, Buchan JR. Liu G, et al. Among authors: coyne an. Nat Commun. 2017 Dec 12;8(1):2092. doi: 10.1038/s41467-017-02017-x. Nat Commun. 2017. PMID: 29233983 Free PMC article.

7

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Zhang K, et al. Among authors: coyne an. Cell. 2018 May 3;173(4):958-971.e17. doi: 10.1016/j.cell.2018.03.025. Epub 2018 Apr 5. Cell. 2018. PMID: 29628143 Free PMC article.

8

G₄C₂ Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. Coyne AN, et al. Neuron. 2020 Sep 23;107(6):1124-1140.e11. doi: 10.1016/j.neuron.2020.06.027. Epub 2020 Jul 15. Neuron. 2020. PMID: 32673563 Free PMC article.

9

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.

Zaepfel BL, Zhang Z, Maulding K, Coyne AN, Cheng W, Hayes LR, Lloyd TE, Sun S, Rothstein JD. Zaepfel BL, et al. Among authors: coyne an. Cell Rep. 2021 Mar 30;34(13):108925. doi: 10.1016/j.celrep.2021.108925. Cell Rep. 2021. PMID: 33789100 Free PMC article.

10

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.

Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. Coyne AN, et al. Sci Transl Med. 2021 Jul 28;13(604):eabe1923. doi: 10.1126/scitranslmed.abe1923. Sci Transl Med. 2021. PMID: 34321318 Free PMC article.

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