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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421
Anthrax lethal factor inhibition.
Shoop WL, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Felcetto T, Michael BF, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Patel SB, Wisniewski D, Scapin G, Salowe SP, Zaller DM, Chapman KT, Scolnick EM, Schmatz DM, Bartizal K, MacCoss M, Hermes JD. Shoop WL, et al. Among authors: cummings rt. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7958-63. doi: 10.1073/pnas.0502159102. Epub 2005 May 23. Proc Natl Acad Sci U S A. 2005. PMID: 15911756 Free PMC article.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB. Wang J, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. doi: 10.1073/pnas.0700746104. Epub 2007 Apr 24. Proc Natl Acad Sci U S A. 2007. PMID: 17456595 Free PMC article.
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
Pandit S, Wisniewski D, Santoro JC, Ha S, Ramakrishnan V, Cubbon RM, Cummings RT, Wright SD, Sparrow CP, Sitlani A, Fisher TS. Pandit S, et al. Among authors: cummings rt. J Lipid Res. 2008 Jun;49(6):1333-43. doi: 10.1194/jlr.M800049-JLR200. Epub 2008 Mar 19. J Lipid Res. 2008. PMID: 18354137 Free article.
59 results