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Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.
Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjærvik E, Zahlsen K, Brunsvik A, Nygaard G, Aachmann FL, Ellingsen TE, Døskeland SO, Zotchev SB. Sletta H, et al. Among authors: doskeland so. Appl Microbiol Biotechnol. 2014 Jan;98(2):603-10. doi: 10.1007/s00253-013-5320-0. Epub 2013 Oct 26. Appl Microbiol Biotechnol. 2014. PMID: 24158735
Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB. Jørgensen H, et al. Among authors: doskeland so. Chem Biol. 2009 Oct 30;16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014. Chem Biol. 2009. PMID: 19875084
The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity.
Oftedal L, Skjærven KH, Coyne RT, Edvardsen B, Rohrlack T, Skulberg OM, Døskeland SO, Herfindal L. Oftedal L, et al. Among authors: doskeland so. J Ind Microbiol Biotechnol. 2011 Apr;38(4):489-501. doi: 10.1007/s10295-010-0791-9. Epub 2010 Aug 6. J Ind Microbiol Biotechnol. 2011. PMID: 20689978 Free PMC article.
Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives.
Viktorsson EÖ, Melling Grøthe B, Aesoy R, Sabir M, Snellingen S, Prandina A, Høgmoen Åstrand OA, Bonge-Hansen T, Døskeland SO, Herfindal L, Rongved P. Viktorsson EÖ, et al. Among authors: doskeland so. Bioorg Med Chem. 2017 Apr 1;25(7):2285-2293. doi: 10.1016/j.bmc.2017.02.058. Epub 2017 Feb 28. Bioorg Med Chem. 2017. PMID: 28284865
189 results