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Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J. Andersen JT, et al. Among authors: dalhus b. J Biol Chem. 2014 May 9;289(19):13492-502. doi: 10.1074/jbc.M114.549832. Epub 2014 Mar 20. J Biol Chem. 2014. PMID: 24652290 Free PMC article.
An intact C-terminal end of albumin is required for its long half-life in humans.
Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT. Nilsen J, et al. Among authors: dalhus b. Commun Biol. 2020 Apr 20;3(1):181. doi: 10.1038/s42003-020-0903-7. Commun Biol. 2020. PMID: 32313072 Free PMC article.
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics.
Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT. Bern M, et al. Among authors: dalhus b. Sci Transl Med. 2020 Oct 14;12(565):eabb0580. doi: 10.1126/scitranslmed.abb0580. Sci Transl Med. 2020. PMID: 33055243
Endonuclease V cleaves at inosines in RNA.
Vik ES, Nawaz MS, Strøm Andersen P, Fladeby C, Bjørås M, Dalhus B, Alseth I. Vik ES, et al. Among authors: dalhus b. Nat Commun. 2013;4:2271. doi: 10.1038/ncomms3271. Nat Commun. 2013. PMID: 23912683 Free PMC article.
79 results