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TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.
Ferreira RR, Abreu RDS, Vilar-Pereira G, Degrave W, Meuser-Batista M, Ferreira NVC, da Cruz Moreira O, da Silva Gomes NL, Mello de Souza E, Ramos IP, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. Among authors: degrave w. PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31365537 Free PMC article.
Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.
Ferrão PM, d'Avila-Levy CM, Araujo-Jorge TC, Degrave WM, Gonçalves Ada S, Garzoni LR, Lima AP, Feige JJ, Bailly S, Mendonça-Lima L, Waghabi MC. Ferrão PM, et al. PLoS One. 2015 May 4;10(5):e0124832. doi: 10.1371/journal.pone.0124832. eCollection 2015. PLoS One. 2015. PMID: 25938232 Free PMC article.
In vitro and in vivo experimental models for drug screening and development for Chagas disease.
Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A. Romanha AJ, et al. Among authors: degrave w. Mem Inst Oswaldo Cruz. 2010 Mar;105(2):233-8. doi: 10.1590/s0074-02762010000200022. Mem Inst Oswaldo Cruz. 2010. PMID: 20428688 Free article.
109 results