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111 results

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Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women.
Thurman AR, Schwartz JL, Brache V, Clark MR, McCormick T, Chandra N, Marzinke MA, Stanczyk FZ, Dezzutti CS, Hillier SL, Herold BC, Fichorova R, Asin SN, Rollenhagen C, Weiner D, Kiser P, Doncel GF. Thurman AR, et al. Among authors: dezzutti cs. PLoS One. 2018 Jun 28;13(6):e0199778. doi: 10.1371/journal.pone.0199778. eCollection 2018. PLoS One. 2018. PMID: 29953547 Free PMC article. Clinical Trial.
Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir Gel.
Herold BC, Chen BA, Salata RA, Marzinke MA, Kelly CW, Dezzutti CS, McGowan I, Galaska B, Levy L, Piper JM, Hillier S, Hendrix CW. Herold BC, et al. Among authors: dezzutti cs. Clin Infect Dis. 2016 Feb 1;62(3):375-382. doi: 10.1093/cid/civ913. Epub 2015 Oct 27. Clin Infect Dis. 2016. PMID: 26508513 Free PMC article.
FAME-04: A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of film and gel formulations of tenofovir.
Bunge KE, Dezzutti CS, Hendrix CW, Marzinke MA, Spiegel HML, Moncla BJ, Schwartz JL, Meyn LA, Richardson-Harman N, Rohan LC, Hillier SL. Bunge KE, et al. Among authors: dezzutti cs. J Int AIDS Soc. 2018 Aug;21(8):e25156. doi: 10.1002/jia2.25156. J Int AIDS Soc. 2018. PMID: 30101439 Free PMC article. Clinical Trial.
Toward early safety alert endpoints: exploring biomarkers suggestive of microbicide failure.
Mauck CK, Lai JJ, Weiner DH, Chandra N, Fichorova RN, Dezzutti CS, Hillier SL, Archer DF, Creinin MD, Schwartz JL, Callahan MM, Doncel GF. Mauck CK, et al. Among authors: dezzutti cs. AIDS Res Hum Retroviruses. 2013 Nov;29(11):1475-86. doi: 10.1089/aid.2012.0345. Epub 2013 Aug 30. AIDS Res Hum Retroviruses. 2013. PMID: 23885658 Clinical Trial.
A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study).
Mcgowan I, Cranston RD, Duffill K, Siegel A, Engstrom JC, Nikiforov A, Jacobson C, Rehman KK, Elliott J, Khanukhova E, Abebe K, Mauck C, Spiegel HM, Dezzutti CS, Rohan LC, Marzinke MA, Hiruy H, Hendrix CW, Richardson-Harman N, Anton PA. Mcgowan I, et al. Among authors: dezzutti cs. PLoS One. 2015 May 5;10(5):e0125363. doi: 10.1371/journal.pone.0125363. eCollection 2015. PLoS One. 2015. PMID: 25942472 Free PMC article. Clinical Trial.
A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film.
Bunge KE, Dezzutti CS, Rohan LC, Hendrix CW, Marzinke MA, Richardson-Harman N, Moncla BJ, Devlin B, Meyn LA, Spiegel HM, Hillier SL. Bunge KE, et al. Among authors: dezzutti cs. J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):498-505. doi: 10.1097/QAI.0000000000000897. J Acquir Immune Defic Syndr. 2016. PMID: 26565716 Free PMC article. Clinical Trial.
Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to Topical Tenofovir.
Noguchi LM, Montgomery ET, Biggio JR, Hendrix CW, Bogen DL, Hillier SL, Dai JY, Piper JM, Marzinke MA, Dezzutti CS, Isaacs SK, Schwartz JL, Watts DH, Beigi RH. Noguchi LM, et al. Among authors: dezzutti cs. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5616-9. doi: 10.1128/AAC.00645-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27401570 Free PMC article.
Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial.
Dezzutti CS, Richardson-Harman N, Rohan LC, Marzinke MA, Hoesley CJ, Panther L, Johnson S, Nuttall JP, Nel A, Chen BA; Microbicide Trials Network, MTN-013/IPM 026 Protocol Team. Dezzutti CS, et al. Medicine (Baltimore). 2016 Jul;95(28):e4174. doi: 10.1097/MD.0000000000004174. Medicine (Baltimore). 2016. PMID: 27428211 Free PMC article. Clinical Trial.
Pharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study With Directly Observed Dosing.
Justman JE, Nair GL, Hendrix CW, Piper JM, Marzinke MA, Dai JY, Pan Z, Galaska B, Levy L, Schwartz JL, Balar B, Kunjara Na Ayudhya RP, Mushamiri I, McGowan I, Dezzutti CS; MTN-014 Study Team. Justman JE, et al. Among authors: dezzutti cs. J Acquir Immune Defic Syndr. 2018 Jun 1;78(2):175-182. doi: 10.1097/QAI.0000000000001655. J Acquir Immune Defic Syndr. 2018. PMID: 29767639 Free PMC article. Clinical Trial.
111 results