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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Draisma HHM, Pool R, Kobl M, Jansen R, Petersen AK, Vaarhorst AAM, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Böhringer S, Beekman M, van Klinken JB, Römisch-Margl W, Prehn C, Adamski J, de Craen AJM, van Leeuwen EM, Amin N, Dharuri H, Westra HJ, Franke L, de Geus EJC, Hottenga JJ, Willemsen G, Henders AK, Montgomery GW, Nyholt DR, Whitfield JB, Penninx BW, Spector TD, Metspalu A, Slagboom PE, van Dijk KW, 't Hoen PAC, Strauch K, Martin NG, van Ommen GB, Illig T, Bell JT, Mangino M, Suhre K, McCarthy MI, Gieger C, Isaacs A, van Duijn CM, Boomsma DI. Draisma HHM, et al. Among authors: dharuri h. Nat Commun. 2015 Jun 12;6:7208. doi: 10.1038/ncomms8208. Nat Commun. 2015. PMID: 26068415 Free PMC article.
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.
Demirkan A, Henneman P, Verhoeven A, Dharuri H, Amin N, van Klinken JB, Karssen LC, de Vries B, Meissner A, Göraler S, van den Maagdenberg AM, Deelder AM, C 't Hoen PA, van Duijn CM, van Dijk KW. Demirkan A, et al. Among authors: dharuri h. PLoS Genet. 2015 Jan 8;11(1):e1004835. doi: 10.1371/journal.pgen.1004835. eCollection 2015 Jan. PLoS Genet. 2015. PMID: 25569235 Free PMC article.
Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium.
van der Spek A, Broer L, Draisma HHM, Pool R, Albrecht E, Beekman M, Mangino M, Raag M, Nyholt DR, Dharuri HK, Codd V, Amin N, de Geus EJC, Deelen J, Demirkan A, Yet I, Fischer K, Haller T, Henders AK, Isaacs A, Medland SE, Montgomery GW, Mooijaart SP, Strauch K, Suchiman HED, Vaarhorst AAM, van Heemst D, Wang-Sattler R, Whitfield JB, Willemsen G, Wright MJ, Martin NG, Samani NJ, Metspalu A, Eline Slagboom P, Spector TD, Boomsma DI, van Duijn CM, Gieger C. van der Spek A, et al. Among authors: dharuri hk. Sci Rep. 2019 Aug 12;9(1):11623. doi: 10.1038/s41598-019-47282-6. Sci Rep. 2019. PMID: 31406173 Free PMC article.
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.
Dharuri H, Henneman P, Demirkan A, van Klinken JB, Mook-Kanamori DO, Wang-Sattler R, Gieger C, Adamski J, Hettne K, Roos M, Suhre K, Van Duijn CM; EUROSPAN Consortia; van Dijk KW, 't Hoen PA. Dharuri H, et al. BMC Genomics. 2013 Dec 9;14:865. doi: 10.1186/1471-2164-14-865. BMC Genomics. 2013. PMID: 24320595 Free PMC article.
Genetics of the human metabolome, what is next?
Dharuri H, Demirkan A, van Klinken JB, Mook-Kanamori DO, van Duijn CM, 't Hoen PA, Willems van Dijk K. Dharuri H, et al. Biochim Biophys Acta. 2014 Oct;1842(10):1923-1931. doi: 10.1016/j.bbadis.2014.05.030. Epub 2014 Jun 4. Biochim Biophys Acta. 2014. PMID: 24905732 Free article. Review.
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.
Dharuri H, 't Hoen PA, van Klinken JB, Henneman P, Laros JF, Lips MA, El Bouazzaoui F, van Ommen GJ, Janssen I, van Ramshorst B, van Wagensveld BA, Pijl H, Willems van Dijk K, van Harmelen V. Dharuri H, et al. Diabetologia. 2014 Nov;57(11):2384-92. doi: 10.1007/s00125-014-3347-0. Epub 2014 Aug 7. Diabetologia. 2014. PMID: 25099943
Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.
Lips MA, Van Klinken JB, van Harmelen V, Dharuri HK, 't Hoen PA, Laros JF, van Ommen GJ, Janssen IM, Van Ramshorst B, Van Wagensveld BA, Swank DJ, Van Dielen F, Dane A, Harms A, Vreeken R, Hankemeier T, Smit JW, Pijl H, Willems van Dijk K. Lips MA, et al. Among authors: dharuri hk. Diabetes Care. 2014 Dec;37(12):3150-6. doi: 10.2337/dc14-0195. Epub 2014 Oct 14. Diabetes Care. 2014. PMID: 25315204 Clinical Trial.
Proteomic analysis in type 2 diabetes patients before and after a very low calorie diet reveals potential disease state and intervention specific biomarkers.
Sleddering MA, Markvoort AJ, Dharuri HK, Jeyakar S, Snel M, Juhasz P, Lynch M, Hines W, Li X, Jazet IM, Adourian A, Hilbers PA, Smit JW, Van Dijk KW. Sleddering MA, et al. Among authors: dharuri hk. PLoS One. 2014 Nov 21;9(11):e112835. doi: 10.1371/journal.pone.0112835. eCollection 2014. PLoS One. 2014. PMID: 25415563 Free PMC article.
Structuring research methods and data with the research object model: genomics workflows as a case study.
Hettne KM, Dharuri H, Zhao J, Wolstencroft K, Belhajjame K, Soiland-Reyes S, Mina E, Thompson M, Cruickshank D, Verdes-Montenegro L, Garrido J, de Roure D, Corcho O, Klyne G, van Schouwen R, 't Hoen PA, Bechhofer S, Goble C, Roos M. Hettne KM, et al. Among authors: dharuri h. J Biomed Semantics. 2014 Sep 18;5(1):41. doi: 10.1186/2041-1480-5-41. eCollection 2014. J Biomed Semantics. 2014. PMID: 25276335 Free PMC article.
13 results