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Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.
Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM. Zahn A, et al. Among authors: di noia jm. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E988-97. doi: 10.1073/pnas.1320486111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591601 Free PMC article.
Pharmacological manipulation of AID.
Methot SP, Di Noia JM. Methot SP, et al. Among authors: di noia jm. Oncotarget. 2015 Sep 29;6(29):26550-1. doi: 10.18632/oncotarget.5269. Oncotarget. 2015. PMID: 26337342 Free PMC article. No abstract available.
A licensing step links AID to transcription elongation for mutagenesis in B cells.
Methot SP, Litzler LC, Subramani PG, Eranki AK, Fifield H, Patenaude AM, Gilmore JC, Santiago GE, Bagci H, Côté JF, Larijani M, Verdun RE, Di Noia JM. Methot SP, et al. Among authors: di noia jm. Nat Commun. 2018 Mar 28;9(1):1248. doi: 10.1038/s41467-018-03387-6. Nat Commun. 2018. PMID: 29593215 Free PMC article.
PRMT5 is essential for B cell development and germinal center dynamics.
Litzler LC, Zahn A, Meli AP, Hébert S, Patenaude AM, Methot SP, Sprumont A, Bois T, Kitamura D, Costantino S, King IL, Kleinman CL, Richard S, Di Noia JM. Litzler LC, et al. Among authors: di noia jm. Nat Commun. 2019 Jan 3;10(1):22. doi: 10.1038/s41467-018-07884-6. Nat Commun. 2019. PMID: 30604754 Free PMC article.
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
Morande PE, Yan XJ, Sepulveda J, Seija N, Marquez ME, Sotelo N, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P. Morande PE, et al. Among authors: di noia jm. Blood. 2021 Jul 22;138(3):246-258. doi: 10.1182/blood.2020008654. Blood. 2021. PMID: 34292322 Free article.
62 results