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Page 1
Discovery of a beta-MSH-derived MC-4R selective agonist.
Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ. Mayer JP, et al. J Med Chem. 2005 May 5;48(9):3095-8. doi: 10.1021/jm0501432. J Med Chem. 2005. PMID: 15857110
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.
Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: dimarchi r. J Neurosci. 2009 May 6;29(18):5916-25. doi: 10.1523/JNEUROSCI.5977-08.2009. J Neurosci. 2009. PMID: 19420258 Free PMC article.
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: dimarchi r. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
Glucagon regulation of energy metabolism.
Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M. Heppner KM, et al. Among authors: dimarchi r. Physiol Behav. 2010 Jul 14;100(5):545-8. doi: 10.1016/j.physbeh.2010.03.019. Epub 2010 Apr 8. Physiol Behav. 2010. PMID: 20381509 Review.
The metabolic actions of glucagon revisited.
Habegger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH. Habegger KM, et al. Among authors: dimarchi r. Nat Rev Endocrinol. 2010 Dec;6(12):689-97. doi: 10.1038/nrendo.2010.187. Epub 2010 Oct 19. Nat Rev Endocrinol. 2010. PMID: 20957001 Free PMC article. Review.
207 results