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Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.
Klarić L, Tsepilov YA, Stanton CM, Mangino M, Sikka TT, Esko T, Pakhomov E, Salo P, Deelen J, McGurnaghan SJ, Keser T, Vučković F, Ugrina I, Krištić J, Gudelj I, Štambuk J, Plomp R, Pučić-Baković M, Pavić T, Vilaj M, Trbojević-Akmačić I, Drake C, Dobrinić P, Mlinarec J, Jelušić B, Richmond A, Timofeeva M, Grishchenko AK, Dmitrieva J, Bermingham ML, Sharapov SZ, Farrington SM, Theodoratou E, Uh HW, Beekman M, Slagboom EP, Louis E, Georges M, Wuhrer M, Colhoun HM, Dunlop MG, Perola M, Fischer K, Polasek O, Campbell H, Rudan I, Wilson JF, Zoldoš V, Vitart V, Spector T, Aulchenko YS, Lauc G, Hayward C. Klarić L, et al. Among authors: dobrinic p. Sci Adv. 2020 Feb 19;6(8):eaax0301. doi: 10.1126/sciadv.aax0301. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128391 Free PMC article.
Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease.
Klasić M, Markulin D, Vojta A, Samaržija I, Biruš I, Dobrinić P, Ventham NT, Trbojević-Akmačić I, Šimurina M, Štambuk J, Razdorov G, Kennedy NA, Satsangi J, Dias AM, Pinho S, Annese V, Latiano A, D'Inca R; IBD consortium; Lauc G, Zoldoš V. Klasić M, et al. Among authors: dobrinic p. Clin Epigenetics. 2018 Jun 4;10:75. doi: 10.1186/s13148-018-0507-y. eCollection 2018. Clin Epigenetics. 2018. PMID: 29991969 Free PMC article.
Repurposing the CRISPR-Cas9 system for targeted DNA methylation.
Vojta A, Dobrinić P, Tadić V, Bočkor L, Korać P, Julg B, Klasić M, Zoldoš V. Vojta A, et al. Among authors: dobrinic p. Nucleic Acids Res. 2016 Jul 8;44(12):5615-28. doi: 10.1093/nar/gkw159. Epub 2016 Mar 11. Nucleic Acids Res. 2016. PMID: 26969735 Free PMC article.
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells.
Rhodes JDP, Feldmann A, Hernández-Rodríguez B, Díaz N, Brown JM, Fursova NA, Blackledge NP, Prathapan P, Dobrinic P, Huseyin MK, Szczurek A, Kruse K, Nasmyth KA, Buckle VJ, Vaquerizas JM, Klose RJ. Rhodes JDP, et al. Among authors: dobrinic p. Cell Rep. 2020 Jan 21;30(3):820-835.e10. doi: 10.1016/j.celrep.2019.12.057. Cell Rep. 2020. PMID: 31968256 Free PMC article.
Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn's Disease (TOPPIC).
Ventham NT, Kennedy NA, Kalla R, Adams AT, Noble A, Ennis H; TOPPIC Study Group; IBD-BIOM Consortium; Mowat C, Dunlop MG, Satsangi J. Ventham NT, et al. Cell Mol Gastroenterol Hepatol. 2023;16(3):431-450. doi: 10.1016/j.jcmgh.2023.06.001. Epub 2023 Jun 17. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37331566 Free PMC article. Clinical Trial.
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.
Šimurina M, de Haan N, Vučković F, Kennedy NA, Štambuk J, Falck D, Trbojević-Akmačić I, Clerc F, Razdorov G, Khon A, Latiano A, D'Incà R, Danese S, Targan S, Landers C, Dubinsky M; Inflammatory Bowel Disease Biomarkers Consortium; McGovern DPB, Annese V, Wuhrer M, Lauc G. Šimurina M, et al. Gastroenterology. 2018 Apr;154(5):1320-1333.e10. doi: 10.1053/j.gastro.2018.01.002. Epub 2018 Jan 6. Gastroenterology. 2018. PMID: 29309774 Free PMC article.