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Monocarboxylate transporter MCT1 is a target for immunosuppression.
Murray CM, Hutchinson R, Bantick JR, Belfield GP, Benjamin AD, Brazma D, Bundick RV, Cook ID, Craggs RI, Edwards S, Evans LR, Harrison R, Holness E, Jackson AP, Jackson CG, Kingston LP, Perry MW, Ross AR, Rugman PA, Sidhu SS, Sullivan M, Taylor-Fishwick DA, Walker PC, Whitehead YM, Wilkinson DJ, Wright A, Donald DK. Murray CM, et al. Among authors: donald dk. Nat Chem Biol. 2005 Dec;1(7):371-6. doi: 10.1038/nchembio744. Nat Chem Biol. 2005. PMID: 16370372
Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
Guile SD, Bantick JR, Cheshire DR, Cooper ME, Davis AM, Donald DK, Evans R, Eyssade C, Ferguson DD, Hill S, Hutchinson R, Ingall AH, Kingston LP, Martin I, Martin BP, Mohammed RT, Murray C, Perry MW, Reynolds RH, Thorne PV, Wilkinson DJ, Withnall J. Guile SD, et al. Among authors: donald dk. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2260-5. doi: 10.1016/j.bmcl.2006.01.024. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455256
The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.
Ekberg H, Qi Z, Pahlman C, Veress B, Bundick RV, Craggs RI, Holness E, Edwards S, Murray CM, Ferguson D, Kerry PJ, Wilson E, Donald DK. Ekberg H, et al. Among authors: donald dk. Transplantation. 2007 Nov 15;84(9):1191-9. doi: 10.1097/01.tp.0000287541.53389.be. Transplantation. 2007. PMID: 17998876
Novel P2X7 receptor antagonists.
Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M. Alcaraz L, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4043-6. doi: 10.1016/j.bmcl.2003.08.033. Bioorg Med Chem Lett. 2003. PMID: 14592504
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
Furber M, Alcaraz L, Bent JE, Beyerbach A, Bowers K, Braddock M, Caffrey MV, Cladingboel D, Collington J, Donald DK, Fagura M, Ince F, Kinchin EC, Laurent C, Lawson M, Luker TJ, Mortimore MM, Pimm AD, Riley RJ, Roberts N, Robertson M, Theaker J, Thorne PV, Weaver R, Webborn P, Willis P. Furber M, et al. Among authors: donald dk. J Med Chem. 2007 Nov 29;50(24):5882-5. doi: 10.1021/jm700949w. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963373
17 results