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Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.
Imamura H, Downing T, Van den Broeck F, Sanders MJ, Rijal S, Sundar S, Mannaert A, Vanaerschot M, Berg M, De Muylder G, Dumetz F, Cuypers B, Maes I, Domagalska M, Decuypere S, Rai K, Uranw S, Bhattarai NR, Khanal B, Prajapati VK, Sharma S, Stark O, Schönian G, De Koning HP, Settimo L, Vanhollebeke B, Roy S, Ostyn B, Boelaert M, Maes L, Berriman M, Dujardin JC, Cotton JA. Imamura H, et al. Among authors: downing t. Elife. 2016 Mar 22;5:e12613. doi: 10.7554/eLife.12613. Elife. 2016. PMID: 27003289 Free PMC article.
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD, de Doncker S, Maes I, Mottram JC, Quail MA, Rijal S, Sanders M, Schönian G, Stark O, Sundar S, Vanaerschot M, Hertz-Fowler C, Dujardin JC, Berriman M. Downing T, et al. Genome Res. 2011 Dec;21(12):2143-56. doi: 10.1101/gr.123430.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038251 Free PMC article.
Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.
Vanaerschot M, Decuypere S, Downing T, Imamura H, Stark O, De Doncker S, Roy S, Ostyn B, Maes L, Khanal B, Boelaert M, Schönian G, Berriman M, Chappuis F, Dujardin JC, Sundar S, Rijal S. Vanaerschot M, et al. Among authors: downing t. J Infect Dis. 2012 Sep 1;206(5):752-5. doi: 10.1093/infdis/jis424. Epub 2012 Jun 29. J Infect Dis. 2012. PMID: 22753945 Free PMC article.
Global genome diversity of the Leishmania donovani complex.
Franssen SU, Durrant C, Stark O, Moser B, Downing T, Imamura H, Dujardin JC, Sanders MJ, Mauricio I, Miles MA, Schnur LF, Jaffe CL, Nasereddin A, Schallig H, Yeo M, Bhattacharyya T, Alam MZ, Berriman M, Wirth T, Schönian G, Cotton JA. Franssen SU, et al. Among authors: downing t. Elife. 2020 Mar 25;9:e51243. doi: 10.7554/eLife.51243. Elife. 2020. PMID: 32209228 Free PMC article.
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.
Shaw CD, Lonchamp J, Downing T, Imamura H, Freeman TM, Cotton JA, Sanders M, Blackburn G, Dujardin JC, Rijal S, Khanal B, Illingworth CJ, Coombs GH, Carter KC. Shaw CD, et al. Among authors: downing t. Mol Microbiol. 2016 Mar;99(6):1134-48. doi: 10.1111/mmi.13291. Epub 2016 Feb 9. Mol Microbiol. 2016. PMID: 26713880 Free PMC article.
Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania.
Mannaert A, Downing T, Imamura H, Dujardin JC. Mannaert A, et al. Among authors: downing t. Trends Parasitol. 2012 Sep;28(9):370-6. doi: 10.1016/j.pt.2012.06.003. Epub 2012 Jul 11. Trends Parasitol. 2012. PMID: 22789456 Free article. Review.
Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains.
Shaw CD, Imamura H, Downing T, Blackburn G, Westrop GD, Cotton JA, Berriman M, Sanders M, Rijal S, Coombs GH, Dujardin JC, Carter KC. Shaw CD, et al. Among authors: downing t. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e00904-19. doi: 10.1128/AAC.00904-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31658971 Free PMC article.
181 results