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Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO. Weischenfeldt J, et al. Among authors: drainas ap. Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21. Nat Genet. 2017. PMID: 27869826 Free PMC article.
A cell-based model system links chromothripsis with hyperploidy.
Mardin BR, Drainas AP, Waszak SM, Weischenfeldt J, Isokane M, Stütz AM, Raeder B, Efthymiopoulos T, Buccitelli C, Segura-Wang M, Northcott P, Pfister SM, Lichter P, Ellenberg J, Korbel JO. Mardin BR, et al. Among authors: drainas ap. Mol Syst Biol. 2015 Sep 28;11(9):828. doi: 10.15252/msb.20156505. Mol Syst Biol. 2015. PMID: 26415501 Free PMC article.
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J. Chaikovsky AC, et al. Among authors: drainas ap. Nature. 2021 Apr;592(7856):794-798. doi: 10.1038/s41586-021-03474-7. Epub 2021 Apr 14. Nature. 2021. PMID: 33854239 Free PMC article.
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Krogan NJ, Jackson PK, Narla G, Gordan JD, Shokat KM, Sage J. Coles GL, et al. Among authors: drainas ap. Cancer Cell. 2020 Jul 13;38(1):129-143.e7. doi: 10.1016/j.ccell.2020.05.003. Epub 2020 Jun 11. Cancer Cell. 2020. PMID: 32531271 Free PMC article.
RB depletion is required for the continuous growth of tumors initiated by loss of RB.
Doan A, Arand J, Gong D, Drainas AP, Shue YT, Lee MC, Zhang S, Walter DM, Chaikovsky AC, Feldser DM, Vogel H, Dow LE, Skotheim JM, Sage J. Doan A, et al. Among authors: drainas ap. PLoS Genet. 2021 Dec 8;17(12):e1009941. doi: 10.1371/journal.pgen.1009941. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34879057 Free PMC article.
Spatial epitope barcoding reveals clonal tumor patch behaviors.
Rovira-Clavé X, Drainas AP, Jiang S, Bai Y, Baron M, Zhu B, Dallas AE, Lee MC, Chu TP, Holzem A, Ayyagari R, Bhattacharya D, McCaffrey EF, Greenwald NF, Markovic M, Coles GL, Angelo M, Bassik MC, Sage J, Nolan GP. Rovira-Clavé X, et al. Among authors: drainas ap. Cancer Cell. 2022 Nov 14;40(11):1423-1439.e11. doi: 10.1016/j.ccell.2022.09.014. Epub 2022 Oct 13. Cancer Cell. 2022. PMID: 36240778 Free PMC article.
The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.
Cristea S, Coles GL, Hornburg D, Gershkovitz M, Arand J, Cao S, Sen T, Williamson SC, Kim JW, Drainas AP, He A, Cam LL, Byers LA, Snyder MP, Contrepois K, Sage J. Cristea S, et al. Among authors: drainas ap. Cancer Res. 2020 Mar 15;80(6):1293-1303. doi: 10.1158/0008-5472.CAN-19-1027. Epub 2020 Jan 22. Cancer Res. 2020. PMID: 31969375 Free PMC article.
15 results