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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
Nicholson G, Rantalainen M, Li JV, Maher AD, Malmodin D, Ahmadi KR, Faber JH, Barrett A, Min JL, Rayner NW, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas ME, Sarkans U; MolPAGE Consortium; Donnelly P, Illig T, Adamski J, Suhre K, Allen M, Zondervan KT, Spector TD, Nicholson JK, Lindon JC, Baunsgaard D, Holmes E, McCarthy MI, Holmes CC. Nicholson G, et al. Among authors: dumas me. PLoS Genet. 2011 Sep;7(9):e1002270. doi: 10.1371/journal.pgen.1002270. Epub 2011 Sep 8. PLoS Genet. 2011. PMID: 21931564 Free PMC article.
Human metabolic profiles are stably controlled by genetic and environmental variation.
Nicholson G, Rantalainen M, Maher AD, Li JV, Malmodin D, Ahmadi KR, Faber JH, Hallgrímsdóttir IB, Barrett A, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas ME, Sarkans U, The Molpage Consortium, Silverman BW, Donnelly P, Nicholson JK, Allen M, Zondervan KT, Lindon JC, Spector TD, McCarthy MI, Holmes E, Baunsgaard D, Holmes CC. Nicholson G, et al. Among authors: dumas me. Mol Syst Biol. 2011 Aug 30;7:525. doi: 10.1038/msb.2011.57. Mol Syst Biol. 2011. PMID: 21878913 Free PMC article.
A metabolic system-wide characterisation of the pig: a model for human physiology.
Merrifield CA, Lewis M, Claus SP, Beckonert OP, Dumas ME, Duncker S, Kochhar S, Rezzi S, Lindon JC, Bailey M, Holmes E, Nicholson JK. Merrifield CA, et al. Among authors: dumas me. Mol Biosyst. 2011 Sep;7(9):2577-88. doi: 10.1039/c1mb05023k. Epub 2011 Jul 14. Mol Biosyst. 2011. PMID: 21761043
Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase.
Cazier JB, Kaisaki PJ, Argoud K, Blaise BJ, Veselkov K, Ebbels TM, Tsang T, Wang Y, Bihoreau MT, Mitchell SC, Holmes EC, Lindon JC, Scott J, Nicholson JK, Dumas ME, Gauguier D. Cazier JB, et al. Among authors: dumas me. J Proteome Res. 2012 Feb 3;11(2):631-42. doi: 10.1021/pr200566t. Epub 2011 Nov 28. J Proteome Res. 2012. PMID: 22029865
Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.
Dumas ME, Domange C, Calderari S, Martínez AR, Ayala R, Wilder SP, Suárez-Zamorano N, Collins SC, Wallis RH, Gu Q, Wang Y, Hue C, Otto GW, Argoud K, Navratil V, Mitchell SC, Lindon JC, Holmes E, Cazier JB, Nicholson JK, Gauguier D. Dumas ME, et al. Genome Med. 2016 Sep 30;8(1):101. doi: 10.1186/s13073-016-0352-6. Genome Med. 2016. PMID: 27716393 Free PMC article.
Colonization-induced host-gut microbial metabolic interaction.
Claus SP, Ellero SL, Berger B, Krause L, Bruttin A, Molina J, Paris A, Want EJ, de Waziers I, Cloarec O, Richards SE, Wang Y, Dumas ME, Ross A, Rezzi S, Kochhar S, Van Bladeren P, Lindon JC, Holmes E, Nicholson JK. Claus SP, et al. Among authors: dumas me. mBio. 2011 Mar 1;2(2):e00271-10. doi: 10.1128/mBio.00271-10. Print 2011. mBio. 2011. PMID: 21363910 Free PMC article.
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. Dumas ME, et al. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6. doi: 10.1073/pnas.0601056103. Epub 2006 Aug 8. Proc Natl Acad Sci U S A. 2006. PMID: 16895997 Free PMC article.
135 results