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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.
Al-Hamashi AA, Koranne R, Dlamini S, Alqahtani A, Karaj E, Rashid MS, Knoff JR, Dunworth M, Pflum MKH, Casero RA Jr, Perera L, Taylor WR, Tillekeratne LMV. Al-Hamashi AA, et al. Among authors: dunworth m. Bioorg Chem. 2021 Nov;116:105297. doi: 10.1016/j.bioorg.2021.105297. Epub 2021 Aug 30. Bioorg Chem. 2021. PMID: 34509798 Free PMC article.
Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.
Zahedi K, Barone S, Destefano-Shields C, Brooks M, Murray-Stewart T, Dunworth M, Li W, Doherty JR, Hall MA, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M. Zahedi K, et al. Among authors: dunworth m. PLoS One. 2017 Sep 8;12(9):e0184570. doi: 10.1371/journal.pone.0184570. eCollection 2017. PLoS One. 2017. PMID: 28886181 Free PMC article.
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Murray-Stewart T, Dunworth M, Foley JR, Schwartz CE, Casero RA Jr. Murray-Stewart T, et al. Among authors: dunworth m. Med Sci (Basel). 2018 Dec 7;6(4):112. doi: 10.3390/medsci6040112. Med Sci (Basel). 2018. PMID: 30544565 Free PMC article.
Dual inhibitors of LSD1 and spermine oxidase.
Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA Jr, Woster PM. Holshouser S, et al. Among authors: dunworth m. Medchemcomm. 2019 Feb 8;10(5):778-790. doi: 10.1039/c8md00610e. eCollection 2019 May 1. Medchemcomm. 2019. PMID: 31191868 Free PMC article.
26 results