Duplantier AJ - Search Results

1

Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.

Duplantier AJ, Beckius GE, Chambers RJ, Chupak LS, Jenkinson TH, Klein AS, Kraus KG, Kudlacz EM, McKechney MW, Pettersson MP, Whitney CA, Milici AJ. Duplantier AJ, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2593-6. doi: 10.1016/s0960-894x(01)00511-x. Bioorg Med Chem Lett. 2001. PMID: 11551757

2

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists.

Kudlacz E, Whitney C, Andresen C, Duplantier A, Beckius G, Chupak L, Klein A, Kraus K, Milici A. Kudlacz E, et al. J Pharmacol Exp Ther. 2002 May;301(2):747-52. doi: 10.1124/jpet.301.2.747. J Pharmacol Exp Ther. 2002. PMID: 11961081

3

SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.

Duplantier AJ, Bachert EL, Cheng JB, Cohan VL, Jenkinson TH, Kraus KG, McKechney MW, Pillar JD, Watson JW. Duplantier AJ, et al. J Med Chem. 2007 Jan 25;50(2):344-9. doi: 10.1021/jm060904g. J Med Chem. 2007. PMID: 17228876

4

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K. Duplantier AJ, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21565499

5

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.

Duplantier AJ, Efremov I, Candler J, Doran AC, Ganong AH, Haas JA, Hanks AN, Kraus KG, Lazzaro JT Jr, Lu J, Maklad N, McCarthy SA, O'Sullivan TJ, Rogers BN, Siuciak JA, Spracklin DK, Zhang L. Duplantier AJ, et al. Bioorg Med Chem Lett. 2009 May 1;19(9):2524-9. doi: 10.1016/j.bmcl.2009.03.032. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19328692

6

Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.

Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW. Duplantier AJ, et al. J Med Chem. 1996 Jan 5;39(1):120-5. doi: 10.1021/jm9505066. J Med Chem. 1996. PMID: 8568798

7

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.

Duplantier AJ, Andresen CJ, Cheng JB, Cohan VL, Decker C, DiCapua FM, Kraus KG, Johnson KL, Turner CR, UmLand JP, Watson JW, Wester RT, Williams AS, Williams JA. Duplantier AJ, et al. J Med Chem. 1998 Jun 18;41(13):2268-77. doi: 10.1021/jm9800090. J Med Chem. 1998. PMID: 9632360

8

1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.

Zhang L, Brodney MA, Candler J, Doran AC, Duplantier AJ, Efremov IV, Evrard E, Kraus K, Ganong AH, Haas JA, Hanks AN, Jenza K, Lazzaro JT, Maklad N, McCarthy SA, Qian W, Rogers BN, Rottas MD, Schmidt CJ, Siuciak JA, Tingley FD 3rd, Zhang AQ. Zhang L, et al. Among authors: duplantier aj. J Med Chem. 2011 Mar 24;54(6):1724-39. doi: 10.1021/jm101414h. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366332

9

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.

Zhang L, Rogers BN, Duplantier AJ, McHardy SF, Efremov I, Berke H, Qian W, Zhang AQ, Maklad N, Candler J, Doran AC, Lazzaro JT Jr, Ganong AH. Zhang L, et al. Among authors: duplantier aj. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5493-6. doi: 10.1016/j.bmcl.2008.09.026. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18812259

10

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

Subramanyam C, Duplantier AJ, Dombroski MA, Chang SP, Gabel CA, Whitney-Pickett C, Perregaux DG, Labasi JM, Yoon K, Shepard RM, Fisher M. Subramanyam C, et al. Among authors: duplantier aj. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5475-9. doi: 10.1016/j.bmcl.2011.06.117. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782426

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