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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
Holmen OL, Zhang H, Fan Y, Hovelson DH, Schmidt EM, Zhou W, Guo Y, Zhang J, Langhammer A, Løchen ML, Ganesh SK, Vatten L, Skorpen F, Dalen H, Zhang J, Pennathur S, Chen J, Platou C, Mathiesen EB, Wilsgaard T, Njølstad I, Boehnke M, Chen YE, Abecasis GR, Hveem K, Willer CJ. Holmen OL, et al. Among authors: fan y. Nat Genet. 2014 Apr;46(4):345-51. doi: 10.1038/ng.2926. Epub 2014 Mar 16. Nat Genet. 2014. PMID: 24633158 Free PMC article.
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Fan Y, Willer CJ, Chen YE. Fan Y, et al. Gastroenterology. 2016 Nov;151(5):1034-1035. doi: 10.1053/j.gastro.2016.08.051. Epub 2016 Aug 30. Gastroenterology. 2016. PMID: 27590687 No abstract available.
Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2.
Fan Y, Wolford BN, Lu H, Liang W, Sun J, Zhou W, Rom O, Mahajan A, Surakka I, Graham SE, Liu Z, Kim H, Ramdas S, Fritsche LG, Nielsen JB, Gabrielsen ME, Hveem K, Yang D, Song J, Garcia-Barrio MT, Zhang J, Liu W, Zhang K, Willer CJ, Chen YE. Fan Y, et al. iScience. 2021 Oct 2;24(11):103196. doi: 10.1016/j.isci.2021.103196. eCollection 2021 Nov 19. iScience. 2021. PMID: 34746691 Free PMC article.
Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.
Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE. Guo Y, et al. Among authors: fan y. J Clin Invest. 2015 Oct 1;125(10):3819-30. doi: 10.1172/JCI79048. Epub 2015 Sep 14. J Clin Invest. 2015. PMID: 26368306 Free PMC article.
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