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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.
Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. Fang EF, et al. Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004. Cell Metab. 2016. PMID: 27732836 Free PMC article.
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA. Scheibye-Knudsen M, et al. Among authors: fang ef. Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4. Cell Metab. 2014. PMID: 25440059 Free PMC article.
Protecting the mitochondrial powerhouse.
Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM 3rd, Bohr VA. Scheibye-Knudsen M, et al. Among authors: fang ef. Trends Cell Biol. 2015 Mar;25(3):158-70. doi: 10.1016/j.tcb.2014.11.002. Epub 2014 Dec 11. Trends Cell Biol. 2015. PMID: 25499735 Free PMC article. Review.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA. Sykora P, et al. Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30. Nucleic Acids Res. 2015. PMID: 25552414 Free PMC article.
A research agenda for aging in China in the 21st century.
Fang EF, Scheibye-Knudsen M, Jahn HJ, Li J, Ling L, Guo H, Zhu X, Preedy V, Lu H, Bohr VA, Chan WY, Liu Y, Ng TB. Fang EF, et al. Ageing Res Rev. 2015 Nov;24(Pt B):197-205. doi: 10.1016/j.arr.2015.08.003. Epub 2015 Aug 22. Ageing Res Rev. 2015. PMID: 26304837 Free PMC article. Review.
DNA Damage, DNA Repair, Aging, and Neurodegeneration.
Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA. Maynard S, et al. Among authors: fang ef. Cold Spring Harb Perspect Med. 2015 Sep 18;5(10):a025130. doi: 10.1101/cshperspect.a025130. Cold Spring Harb Perspect Med. 2015. PMID: 26385091 Free PMC article. Review.
132 results