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Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.
Jean-Pierre N, Barnable P, Kizima L, Rodríguez A, Seidor S, Cooney ML, Clark MR, Doncel GF, Robbiani M, Zydowsky TM, Teleshova N, Fernández-Romero JA. Jean-Pierre N, et al. Antimicrob Agents Chemother. 2015 Nov 23;60(2):1141-4. doi: 10.1128/AAC.02468-15. Print 2016 Feb. Antimicrob Agents Chemother. 2015. PMID: 26596943 Free PMC article.
Carrageenan/MIV-150 (PC-815), a combination microbicide.
Fernández-Romero JA, Thorn M, Turville SG, Titchen K, Sudol K, Li J, Miller T, Robbiani M, Maguire RA, Buckheit RW Jr, Hartman TL, Phillips DM. Fernández-Romero JA, et al. Sex Transm Dis. 2007 Jan;34(1):9-14. doi: 10.1097/01.olq.0000223287.46097.4b. Sex Transm Dis. 2007. PMID: 16924181
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.
Kenney J, Aravantinou M, Singer R, Hsu M, Rodriguez A, Kizima L, Abraham CJ, Menon R, Seidor S, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M. Kenney J, et al. PLoS One. 2011 Jan 5;6(1):e15835. doi: 10.1371/journal.pone.0015835. PLoS One. 2011. PMID: 21246052 Free PMC article.
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.
Singer R, Derby N, Rodriguez A, Kizima L, Kenney J, Aravantinou M, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M. Singer R, et al. J Virol. 2011 Jun;85(11):5504-12. doi: 10.1128/JVI.02422-10. Epub 2011 Mar 16. J Virol. 2011. PMID: 21411526 Free PMC article.
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.
Fernández-Romero JA, Abraham CJ, Rodriguez A, Kizima L, Jean-Pierre N, Menon R, Begay O, Seidor S, Ford BE, Gil PI, Peters J, Katz D, Robbiani M, Zydowsky TM. Fernández-Romero JA, et al. Antimicrob Agents Chemother. 2012 Jan;56(1):358-68. doi: 10.1128/AAC.05461-11. Epub 2011 Nov 7. Antimicrob Agents Chemother. 2012. PMID: 22064530 Free PMC article.
A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.
Kenney J, Singer R, Derby N, Aravantinou M, Abraham CJ, Menon R, Seidor S, Zhang S, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Zydowsky TM, Robbiani M. Kenney J, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1476-84. doi: 10.1089/aid.2012.0087. Epub 2012 Jul 30. AIDS Res Hum Retroviruses. 2012. PMID: 22737981 Free PMC article.
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.
Aravantinou M, Singer R, Derby N, Calenda G, Mawson P, Abraham CJ, Menon R, Seidor S, Goldman D, Kenney J, Villegas G, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Teleshova N, Robbiani M. Aravantinou M, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1467-75. doi: 10.1089/aid.2012.0080. Epub 2012 Aug 27. AIDS Res Hum Retroviruses. 2012. PMID: 22816564 Free PMC article.
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.
Singer R, Mawson P, Derby N, Rodriguez A, Kizima L, Menon R, Goldman D, Kenney J, Aravantinou M, Seidor S, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Robbiani M, Zydowsky TM. Singer R, et al. Sci Transl Med. 2012 Sep 5;4(150):150ra123. doi: 10.1126/scitranslmed.3003936. Sci Transl Med. 2012. PMID: 22956201 Free PMC article.
40 results