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The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM. Carroll B, et al. Among authors: francis re. Dev Cell. 2013 Apr 15;25(1):15-28. doi: 10.1016/j.devcel.2013.03.005. Epub 2013 Apr 4. Dev Cell. 2013. PMID: 23562278 Free PMC article.
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.
Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR, Braga VM. Frasa MA, et al. Among authors: francis re. Curr Biol. 2010 Feb 9;20(3):198-208. doi: 10.1016/j.cub.2009.12.053. Epub 2010 Jan 28. Curr Biol. 2010. PMID: 20116244 Free article.
FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.
Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW. Francis RE, et al. Int J Oncol. 2009 Jul;35(1):57-68. doi: 10.3892/ijo_00000313. Int J Oncol. 2009. PMID: 19513552 Free PMC article.
Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer.
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM, Polychronis A, Coombes RC, Lam EW. McGovern UB, et al. Among authors: francis re. Mol Cancer Ther. 2009 Mar;8(3):582-91. doi: 10.1158/1535-7163.MCT-08-0805. Epub 2009 Mar 10. Mol Cancer Ther. 2009. PMID: 19276163 Free article.