Frayling TM - Search Results

1

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R. Wang H, et al. Among authors: frayling tm. Nat Commun. 2019 Aug 13;10(1):3503. doi: 10.1038/s41467-019-11456-7. Nat Commun. 2019. PMID: 31409809 Free PMC article.

2

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: frayling tm. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637

3

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

Mitchell SM, Weedon MN, Owen KR, Shields B, Wilkins-Wall B, Walker M, McCarthy MI, Frayling TM, Hattersley AT. Mitchell SM, et al. Among authors: frayling tm. Diabetes. 2003 May;52(5):1276-9. doi: 10.2337/diabetes.52.5.1276. Diabetes. 2003. PMID: 12716764

4

Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population.

Weedon MN, Turner M, Knight B, Clark P, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: frayling tm. Clin Endocrinol (Oxf). 2003 Aug;59(2):175-9. doi: 10.1046/j.1365-2265.2003.01797.x. Clin Endocrinol (Oxf). 2003. PMID: 12864794

5

Tall stories: the fundamental difficulties of genetic association studies.

Weedon MN, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: frayling tm. Clin Endocrinol (Oxf). 2004 Jan;60(1):145-6. doi: 10.1111/j.1365-2265.2004.01950.x. Clin Endocrinol (Oxf). 2004. PMID: 14678302 No abstract available.

6

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: frayling tm. Diabetes. 2005 Aug;54(8):2487-91. doi: 10.2337/diabetes.54.8.2487. Diabetes. 2005. PMID: 16046319

7

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.

Freathy RM, Weedon MN, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM. Freathy RM, et al. Among authors: frayling tm. JOP. 2006 May 9;7(3):295-302. JOP. 2006. PMID: 16685110

8

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.

Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM. Freathy RM, et al. Among authors: frayling tm. BMC Med Genet. 2006 Jun 5;7:51. doi: 10.1186/1471-2350-7-51. BMC Med Genet. 2006. PMID: 16753056 Free PMC article.

9

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.

Gloyn AL, Mackay DJ, Weedon MN, McCarthy MI, Walker M, Hitman G, Knight BA, Owen KR, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: frayling tm. Diabetes. 2006 Aug;55(8):2272-6. doi: 10.2337/db06-0216. Diabetes. 2006. PMID: 16873690

10

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: frayling tm. Diabetes. 2006 Sep;55(9):2640-4. doi: 10.2337/db06-0355. Diabetes. 2006. PMID: 16936215

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