Frayling TM - Search Results

1

Using human genetics to understand the disease impacts of testosterone in men and women.

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B, O'Mara TA; Endometrial Cancer Association Consortium; McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB. Ruth KS, et al. Among authors: frayling tm. Nat Med. 2020 Feb;26(2):252-258. doi: 10.1038/s41591-020-0751-5. Epub 2020 Feb 10. Nat Med. 2020. PMID: 32042192 Free PMC article.

2

Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.

Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, Barrett T, Frayling TM. Minton JA, et al. Among authors: frayling tm. Diabetes. 2002 Apr;51(4):1287-90. doi: 10.2337/diabetes.51.4.1287. Diabetes. 2002. PMID: 11916957

3

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

Haddad L, Evans JC, Gharani N, Robertson C, Rush K, Wiltshire S, Frayling TM, Wilkin TJ, Demaine A, Millward A, Hattersley AT, Conway G, Cox NJ, Bell GI, Franks S, McCarthy MI. Haddad L, et al. Among authors: frayling tm. J Clin Endocrinol Metab. 2002 Jun;87(6):2606-10. doi: 10.1210/jcem.87.6.8608. J Clin Endocrinol Metab. 2002. PMID: 12050223

4

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: frayling tm. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637

5

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: frayling tm. Diabetes. 2003 May;52(5):1300-5. doi: 10.2337/diabetes.52.5.1300. Diabetes. 2003. PMID: 12716770

6

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.

Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT. Frayling TM, et al. Diabetes. 2003 Jul;52(7):1857-63. doi: 10.2337/diabetes.52.7.1857. Diabetes. 2003. PMID: 12829657

7

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.

Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S, Hattersley AT, Cardon LR, McCarthy MI. Wiltshire S, et al. Among authors: frayling tm. Diabetes. 2004 Mar;53(3):855-60. doi: 10.2337/diabetes.53.3.855. Diabetes. 2004. PMID: 14988275

8

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: frayling tm. Diabetes. 2004 Nov;53(11):3002-6. doi: 10.2337/diabetes.53.11.3002. Diabetes. 2004. PMID: 15504983

9

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI. Zeggini E, et al. Among authors: frayling tm. Diabetes. 2004 Dec;53(12):3319-22. doi: 10.2337/diabetes.53.12.3319. Diabetes. 2004. PMID: 15561966

10

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: frayling tm. Diabetes. 2005 Aug;54(8):2487-91. doi: 10.2337/diabetes.54.8.2487. Diabetes. 2005. PMID: 16046319

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