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Page 1
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M. Hyslop LA, et al. Nature. 2016 Jun 16;534(7607):383-6. doi: 10.1038/nature18303. Epub 2016 Jun 8. Nature. 2016. PMID: 27281217 Free PMC article.
Mitochondrial DNA disease: new options for prevention.
Craven L, Elson JL, Irving L, Tuppen HA, Lister LM, Greggains GD, Byerley S, Murdoch AP, Herbert M, Turnbull D. Craven L, et al. Hum Mol Genet. 2011 Oct 15;20(R2):R168-74. doi: 10.1093/hmg/ddr373. Epub 2011 Aug 18. Hum Mol Genet. 2011. PMID: 21852248 Free PMC article. Review.
Nuclear transfer and iPS may work best together.
Gurdon J, Murdoch A. Gurdon J, et al. Cell Stem Cell. 2008 Feb 7;2(2):135-8. doi: 10.1016/j.stem.2008.01.009. Cell Stem Cell. 2008. PMID: 18371434 Free article.