Garcin ED - Search Results

1

DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.

Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Björas M, Cunningham RP, Tainer JA. Garcin ED, et al. Nat Struct Mol Biol. 2008 May;15(5):515-22. doi: 10.1038/nsmb.1414. Epub 2008 Apr 13. Nat Struct Mol Biol. 2008. PMID: 18408731

2

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Garcin ED, et al. J Biol Chem. 2004 Sep 3;279(36):37918-27. doi: 10.1074/jbc.M406204200. Epub 2004 Jun 17. J Biol Chem. 2004. PMID: 15208315 Free article.

3

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED. Garcin ED, et al. Nat Chem Biol. 2008 Nov;4(11):700-7. doi: 10.1038/nchembio.115. Epub 2008 Oct 12. Nat Chem Biol. 2008. PMID: 18849972 Free PMC article.

4

Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED. Rosenfeld RJ, et al. Among authors: garcin ed. Biochemistry. 2002 Nov 26;41(47):13915-25. doi: 10.1021/bi026313j. Biochemistry. 2002. PMID: 12437348

5

Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED. Seeger F, et al. Among authors: garcin ed. Biochemistry. 2014 Apr 8;53(13):2153-65. doi: 10.1021/bi500129k. Epub 2014 Mar 26. Biochemistry. 2014. PMID: 24669844 Free PMC article.

6

C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.

Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. Tiso M, et al. Among authors: garcin ed. J Biol Chem. 2005 Nov 25;280(47):39208-19. doi: 10.1074/jbc.M507775200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16150731 Free article.

7

The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.

Wei CC, Wang ZQ, Durra D, Hemann C, Hille R, Garcin ED, Getzoff ED, Stuehr DJ. Wei CC, et al. Among authors: garcin ed. J Biol Chem. 2005 Mar 11;280(10):8929-35. doi: 10.1074/jbc.M409737200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632185 Free article.

8

Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer.

Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ. Guan ZW, et al. Among authors: garcin ed. J Biol Chem. 2010 Jan 29;285(5):3064-75. doi: 10.1074/jbc.M109.000810. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948738 Free PMC article.

9

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.

Rogers NM, Seeger F, Garcin ED, Roberts DD, Isenberg JS. Rogers NM, et al. Among authors: garcin ed. Front Physiol. 2014 Apr 4;5:134. doi: 10.3389/fphys.2014.00134. eCollection 2014. Front Physiol. 2014. PMID: 24772092 Free PMC article. Review.

10

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. Sarkar A, et al. Among authors: garcin ed. J Biol Chem. 2015 Aug 28;290(35):21615-28. doi: 10.1074/jbc.M115.645515. Epub 2015 Jul 1. J Biol Chem. 2015. PMID: 26134567 Free PMC article.

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