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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes.
Liu P, Hu Z, DuBois BG, Moyes CR, Hunter DN, Zhu C, Kar NF, Zhu Y, Garfunkle J, Kang L, Chicchi G, Ehrhardt A, Woods A, Seo T, Woods M, van Heek M, Dingley KH, Pang J, Salituro GM, Powell J, Terebetski JL, Hornak V, Campeau LC, Lamberson J, Ujjainwalla F, Miller M, Stamford A, Wood HB, Kowalski T, Nargund RP, Edmondson SD. Liu P, et al. Among authors: garfunkle j. ACS Med Chem Lett. 2015 Jul 10;6(8):936-41. doi: 10.1021/acsmedchemlett.5b00207. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288697 Free PMC article.
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Kimball FS, et al. Among authors: garfunkle j. J Med Chem. 2008 Feb 28;51(4):937-47. doi: 10.1021/jm701210y. Epub 2008 Feb 5. J Med Chem. 2008. PMID: 18247553 Free PMC article.
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.
Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Mileni M, et al. Among authors: garfunkle j. J Am Chem Soc. 2011 Mar 23;133(11):4092-100. doi: 10.1021/ja110877y. Epub 2011 Feb 28. J Am Chem Soc. 2011. PMID: 21355555 Free PMC article.