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Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
Singh SB, Jayasuriya H, Ondeyka JG, Herath KB, Zhang C, Zink DL, Tsou NN, Ball RG, Basilio A, Genilloud O, Diez MT, Vicente F, Pelaez F, Young K, Wang J. Singh SB, et al. Among authors: genilloud o. J Am Chem Soc. 2006 Sep 13;128(36):11916-20. doi: 10.1021/ja062232p. J Am Chem Soc. 2006. PMID: 16953632
Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.
Lingham RB, Hsu AH, O'Brien JA, Sigmund JM, Sanchez M, Gagliardi MM, Heimbuch BK, Genilloud O, Martin I, Diez MT, Hirsch CF, Zink DL, Liesch JM, Koch GE, Gartner SE, Garrity GM, Tsou NN, Salituro GM. Lingham RB, et al. Among authors: o brien ja, genilloud o. J Antibiot (Tokyo). 1996 Mar;49(3):253-9. doi: 10.7164/antibiotics.49.253. J Antibiot (Tokyo). 1996. PMID: 8626240 Free article.
Inhibitors of farnesylation of Ras from a microbial natural products screening program.
Vilella D, Sánchez M, Platas G, Salazar O, Genilloud O, Royo I, Cascales C, Martín I, Díez T, Silverman KC, Lingham RB, Singh SB, Jayasuriya H, Peláez F. Vilella D, et al. Among authors: genilloud o. J Ind Microbiol Biotechnol. 2000 Dec;25(6):315-327. doi: 10.1038/sj.jim.7000085. J Ind Microbiol Biotechnol. 2000. PMID: 11320419
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
Singh SB, Jayasuriya H, Salituro GM, Zink DL, Shafiee A, Heimbuch B, Silverman KC, Lingham RB, Genilloud O, Teran A, Vilella D, Felock P, Hazuda D. Singh SB, et al. Among authors: genilloud o. J Nat Prod. 2001 Jul;64(7):874-82. doi: 10.1021/np000632z. J Nat Prod. 2001. PMID: 11473415
Durhamycin A, a potent inhibitor of HIV Tat transactivation.
Jayasuriya H, Lingham RB, Graham P, Quamina D, Herranz L, Genilloud O, Gagliardi M, Danzeisen R, Tomassini JE, Zink DL, Guan Z, Singh SB. Jayasuriya H, et al. Among authors: genilloud o. J Nat Prod. 2002 Aug;65(8):1091-5. doi: 10.1021/np010642f. J Nat Prod. 2002. PMID: 12193009
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Among authors: genilloud o. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421
181 results