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Plasmodium falciparum heat shock proteins as antimalarial drug targets: An update.
Ahmad T, Alhammadi BA, Almaazmi SY, Arafa S, Blatch GL, Dutta T, Gestwicki JE, Keyzers RA, Shonhai A, Singh H. Ahmad T, et al. Among authors: gestwicki je. Cell Stress Chaperones. 2024 Apr;29(2):326-337. doi: 10.1016/j.cstres.2024.03.007. Epub 2024 Mar 20. Cell Stress Chaperones. 2024. PMID: 38518861 Free PMC article. Review.
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
Tanaka M, Fujikawa R, Sekiguchi T, Hernandez J, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Hoang Trung H, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE, Kuramoto T. Tanaka M, et al. Among authors: gestwicki je. Front Neurosci. 2024 Feb 6;18:1263724. doi: 10.3389/fnins.2024.1263724. eCollection 2024. Front Neurosci. 2024. PMID: 38384479 Free PMC article.
An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.
Thompson AD, Wagner MJ, Rodriguez J, Malhotra A, Vander Roest S, Lilienthal U, Shao H, Vignesh M, Weber K, Yob JM, Prosser BL, Helms AS, Gestwicki JE, Ginsburg D, Day SM. Thompson AD, et al. Among authors: gestwicki je. JACC Basic Transl Sci. 2023 Aug 2;8(9):1198-1211. doi: 10.1016/j.jacbts.2023.04.009. eCollection 2023 Sep. JACC Basic Transl Sci. 2023. PMID: 37791314 Free PMC article.
De novo designed Hsp70 activator dissolves intracellular condensates.
Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D. Zhang JZ, et al. Among authors: gestwicki je. bioRxiv [Preprint]. 2023 Sep 19:2023.09.18.558356. doi: 10.1101/2023.09.18.558356. bioRxiv. 2023. PMID: 37781598 Free PMC article. Preprint.
Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.
Echtenkamp FJ, Ishida R, Rivera-Marquez GM, Maisiak M, Johnson OT, Shrimp JH, Sinha A, Ralph SJ, Nisbet I, Cherukuri MK, Gestwicki JE, Neckers LM. Echtenkamp FJ, et al. Among authors: gestwicki je. PNAS Nexus. 2023 Apr 3;2(4):pgad115. doi: 10.1093/pnasnexus/pgad115. eCollection 2023 Apr. PNAS Nexus. 2023. PMID: 37091547 Free PMC article.
225 results