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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Weng D, et al. Among authors: gough pj. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5. Proc Natl Acad Sci U S A. 2014. PMID: 24799678 Free PMC article.
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Garcia-Carbonell R, et al. Among authors: gough pj. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12. Proc Natl Acad Sci U S A. 2018. PMID: 30209212 Free PMC article.
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES. Kaiser WJ, et al. Among authors: gough pj. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7753-8. doi: 10.1073/pnas.1401857111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821786 Free PMC article.
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Orning P, et al. Among authors: gough pj. Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25. Science. 2018. PMID: 30361383 Free PMC article.
Absence of RIPK3 predicts necroptosis resistance in malignant melanoma.
Geserick P, Wang J, Schilling R, Horn S, Harris PA, Bertin J, Gough PJ, Feoktistova M, Leverkus M. Geserick P, et al. Among authors: gough pj. Cell Death Dis. 2015 Sep 10;6(9):e1884. doi: 10.1038/cddis.2015.240. Cell Death Dis. 2015. PMID: 26355347 Free PMC article.
Drilling into RIP1 biology: what compounds are in your toolkit?
Berger SB, Bertin J, Gough PJ. Berger SB, et al. Among authors: gough pj. Cell Death Dis. 2015 Sep 17;6(9):e1889. doi: 10.1038/cddis.2015.254. Cell Death Dis. 2015. PMID: 26379194 Free PMC article. No abstract available.
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES. Kaiser WJ, et al. Among authors: gough pj. J Biol Chem. 2013 Oct 25;288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9. J Biol Chem. 2013. PMID: 24019532 Free PMC article.
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ. Berger SB, et al. Among authors: gough pj. J Immunol. 2014 Jun 15;192(12):5476-80. doi: 10.4049/jimmunol.1400499. Epub 2014 May 12. J Immunol. 2014. PMID: 24821972 Free PMC article.
105 results