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The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Crippa V, Cicardi ME, Ramesh N, Seguin SJ, Ganassi M, Bigi I, Diacci C, Zelotti E, Baratashvili M, Gregory JM, Dobson CM, Cereda C, Pandey UB, Poletti A, Carra S. Crippa V, et al. Among authors: gregory jm. Hum Mol Genet. 2016 Sep 15;25(18):3908-3924. doi: 10.1093/hmg/ddw232. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466192 Free PMC article.
Clusterin protects neurons against intracellular proteotoxicity.
Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR. Gregory JM, et al. Acta Neuropathol Commun. 2017 Nov 7;5(1):81. doi: 10.1186/s40478-017-0481-1. Acta Neuropathol Commun. 2017. PMID: 29115989 Free PMC article.
Probing TDP-43 condensation using an in silico designed aptamer.
Zacco E, Kantelberg O, Milanetti E, Armaos A, Panei FP, Gregory J, Jeacock K, Clarke DJ, Chandran S, Ruocco G, Gustincich S, Horrocks MH, Pastore A, Tartaglia GG. Zacco E, et al. Nat Commun. 2022 Jun 23;13(1):3306. doi: 10.1038/s41467-022-30944-x. Nat Commun. 2022. PMID: 35739092 Free PMC article.
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.
Spence H, Waldron FM, Saleeb RS, Brown AL, Rifai OM, Gilodi M, Read F, Roberts K, Milne G, Wilkinson D, O'Shaughnessy J, Pastore A, Fratta P, Shneider N, Tartaglia GG, Zacco E, Horrocks MH, Gregory JM. Spence H, et al. Among authors: gregory jm. Acta Neuropathol. 2024 Mar 5;147(1):50. doi: 10.1007/s00401-024-02705-1. Acta Neuropathol. 2024. PMID: 38443601 Free PMC article.
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
Mehta AR, Gregory JM, Dando O, Carter RN, Burr K, Nanda J, Story D, McDade K, Smith C, Morton NM, Mahad DJ, Hardingham GE, Chandran S, Selvaraj BT. Mehta AR, et al. Among authors: gregory jm. Acta Neuropathol. 2021 Feb;141(2):257-279. doi: 10.1007/s00401-020-02252-5. Epub 2021 Jan 4. Acta Neuropathol. 2021. PMID: 33398403 Free PMC article.
114 results