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PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption.
Stechschulte LA, Czernik PJ, Rotter ZC, Tausif FN, Corzo CA, Marciano DP, Asteian A, Zheng J, Bruning JB, Kamenecka TM, Rosen CJ, Griffin PR, Lecka-Czernik B. Stechschulte LA, et al. Among authors: griffin pr. EBioMedicine. 2016 Aug;10:174-84. doi: 10.1016/j.ebiom.2016.06.040. Epub 2016 Jun 29. EBioMedicine. 2016. PMID: 27422345 Free PMC article.
An alternate binding site for PPARγ ligands.
Hughes TS, Giri PK, de Vera IM, Marciano DP, Kuruvilla DS, Shin Y, Blayo AL, Kamenecka TM, Burris TP, Griffin PR, Kojetin DJ. Hughes TS, et al. Among authors: griffin pr. Nat Commun. 2014 Apr 7;5:3571. doi: 10.1038/ncomms4571. Nat Commun. 2014. PMID: 24705063 Free PMC article.
Identification of Bexarotene as a PPARγ Antagonist with HDX.
Marciano DP, Kuruvilla DS, Pascal BD, Griffin PR. Marciano DP, et al. Among authors: griffin pr. PPAR Res. 2015;2015:254560. doi: 10.1155/2015/254560. Epub 2015 Sep 15. PPAR Res. 2015. PMID: 26451138 Free PMC article.
SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism.
van Marrewijk LM, Polyak SW, Hijnen M, Kuruvilla D, Chang MR, Shin Y, Kamenecka TM, Griffin PR, Bruning JB. van Marrewijk LM, et al. Among authors: griffin pr. ACS Chem Biol. 2016 Jan 15;11(1):273-83. doi: 10.1021/acschembio.5b00580. Epub 2015 Dec 3. ACS Chem Biol. 2016. PMID: 26579553 Free PMC article.
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
Frkic RL, He Y, Rodriguez BB, Chang MR, Kuruvilla D, Ciesla A, Abell AD, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. Among authors: griffin pr. J Med Chem. 2017 Jun 8;60(11):4584-4593. doi: 10.1021/acs.jmedchem.6b01727. Epub 2017 May 22. J Med Chem. 2017. PMID: 28485590 Free PMC article.
279 results