Cytochrome P450 destruction and radical scavenging by benzene and its metabolites. Evidence for the key role of quinones.
Soucek P, Filipcova B, Gut I.
Soucek P, et al. Among authors: gut i.
Biochem Pharmacol. 1994 Jun 15;47(12):2233-42. doi: 10.1016/0006-2952(94)90261-5.
Biochem Pharmacol. 1994.
PMID: 8031317
Exposure to benzene was reported to lower the cytochrome P450 (CYP; EC 1.14.14.1) content in phenobarbital-pretreated (PB) rats in vivo (Gut I, Zbl Pharm 122: 1139-1161, 1983). In this paper we followed the ability of benzene and its metabolites, phenol, catechol, h …
Exposure to benzene was reported to lower the cytochrome P450 (CYP; EC 1.14.14.1) content in phenobarbital-pretreated (PB) rats in vivo ( …