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Page 1
Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity.
Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW. Gadhiya S, et al. Bioorg Med Chem. 2016 May 1;24(9):2060-71. doi: 10.1016/j.bmc.2016.03.037. Epub 2016 Mar 21. Bioorg Med Chem. 2016. PMID: 27032890 Free PMC article.
Two series of analogues of the tetrahydroprotoberberine (THPB) alkaloid ()-stepholidine that (a) contain various alkoxy substituents at the C10 position and, (b) were de-rigidified with respect to ()-stepholidine, were synthesized and evaluated for affinity at dopamine and sigma …
Two series of analogues of the tetrahydroprotoberberine (THPB) alkaloid ()-stepholidine that (a) contain various alkoxy substituents at the …
Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands.
Sahn JJ, Hodges TR, Chan JZ, Martin SF. Sahn JJ, et al. ChemMedChem. 2016 Mar 17;11(6):556-61. doi: 10.1002/cmdc.201500551. Epub 2016 Feb 24. ChemMedChem. 2016. PMID: 26915462 Free PMC article.
Emerging evidence has implicated the sigma 2 receptor in multiple health disorders, so the drug-like characteristics of many of the selective sigma 2 receptor ligands disclosed herein, coupled with their structural similarity to frameworks found in known drugs, suggest tha …
Emerging evidence has implicated the sigma 2 receptor in multiple health disorders, so the drug-like characteristics of many of the s …
Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.
Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Tosh DK, et al. J Med Chem. 2016 Apr 14;59(7):3249-63. doi: 10.1021/acs.jmedchem.5b01998. Epub 2016 Feb 18. J Med Chem. 2016. PMID: 26890707 Free PMC article.
Purine (N)-methanocarba-5'-N-alkyluronamidoriboside A3 adenosine receptor (A3AR) agonists lacking an exocyclic amine resulted from an unexpected reaction during a Sonogashira coupling and subsequent aminolysis. ...Of these, the C6-Me-(2-phenylethynyl) and C2-(5-chlo …
Purine (N)-methanocarba-5'-N-alkyluronamidoriboside A3 adenosine receptor (A3AR) agonists lacking an exocyclic amine resulted …
Demographically Corrected Normative Standards for the Spanish Language Version of the NIH Toolbox Cognition Battery.
Casaletto KB, Umlauf A, Marquine M, Beaumont JL, Mungas D, Gershon R, Slotkin J, Akshoomoff N, Heaton RK. Casaletto KB, et al. J Int Neuropsychol Soc. 2016 Mar;22(3):364-74. doi: 10.1017/S135561771500137X. Epub 2016 Jan 28. J Int Neuropsychol Soc. 2016. PMID: 26817924 Free PMC article.
Hispanics are the fastest growing ethnicity in the United States, yet there are limited well-validated neuropsychological tools in Spanish, and an even greater paucity of normative standards representing this population. ...
Hispanics are the fastest growing ethnicity in the United States, yet there are limited well-validated neuropsychological tool …
Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.
Janowsky A, Tosh DK, Eshleman AJ, Jacobson KA. Janowsky A, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):24-35. doi: 10.1124/jpet.115.229666. Epub 2016 Jan 26. J Pharmacol Exp Ther. 2016. PMID: 26813929 Free PMC article.
Thirty-two congeneric rigid adenine nucleoside derivatives containing a North (N)-methanocarba ribose substitution and a 2-arylethynyl group either enhanced (up to 760% of control) or inhibited [(125)I] methyl (1R,2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane- …
Thirty-two congeneric rigid adenine nucleoside derivatives containing a North (N)-methanocarba ribose substitution and a 2-arylethyny …
An Information Needs Assessment of School Nurses in a Metropolitan County.
Schweikhard AJ. Schweikhard AJ. Med Ref Serv Q. 2016;35(1):27-41. doi: 10.1080/02763869.2016.1117287. Med Ref Serv Q. 2016. PMID: 26794194 Free PMC article.
School nurses are an integral though often underserved population within the health care and education professions. To develop an effective outreach program for this group, an academic health sciences library conducted an information needs assessment of public schoo …
School nurses are an integral though often underserved population within the health care and education professions. To develop an eff …
Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp.
Almeida C, El Maddah F, Kehraus S, Schnakenburg G, König GM. Almeida C, et al. Org Lett. 2016 Feb 5;18(3):528-31. doi: 10.1021/acs.orglett.5b03553. Epub 2016 Jan 15. Org Lett. 2016. PMID: 26771858
Culture on a biomalt medium supplemented with sea salt led to the isolation of two new, most unusual N-methylated peptides, i.e., the tetrapeptides endolide A and B (1 and 2). ...
Culture on a biomalt medium supplemented with sea salt led to the isolation of two new, most unusual N-methylated peptides, i.e., the …
185 results