Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.
Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE.
Hadfield A, et al.
Biochemistry. 2001 Dec 4;40(48):14475-83. doi: 10.1021/bi015713o.
Biochemistry. 2001.
PMID: 11724560
Comparison of the previously determined apo-enzyme structure [Hadfield et al. J. Mol. Biol. (1999) 289, 991-1002] and the complex presented here reveals a conformational change that occurs on binding of NADP that creates a binding site for the amino acid subs …
Comparison of the previously determined apo-enzyme structure [Hadfield et al. J. Mol. Biol. (1999) 289, 991-1002] and the complex pre …