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The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.
Lin LS, Kopka IE, Mumford RA, Magriotis PA, Lanza T Jr, Durette PL, Kamenecka T, Young DN, de Laszlo SE, McCauley E, Riper GV, Kidambi U, Egger LA, Tong X, Lyons K, Vincent S, Stearns R, Colletti A, Teffera Y, Fenyk-Melody J, Schmidt JA, MacCoss M, Hagmann WK. Lin LS, et al. Among authors: hagmann wk. Bioorg Med Chem Lett. 2002 Feb 25;12(4):611-4. doi: 10.1016/s0960-894x(01)00818-6. Bioorg Med Chem Lett. 2002. PMID: 11844683
Glycolipids as host resistance stimulators.
Ponpipom MM, Hagmann WK, O'Grady LA, Jackson JJ, Wood DD, Zweerink HJ. Ponpipom MM, et al. Among authors: hagmann wk. J Med Chem. 1990 Feb;33(2):861-7. doi: 10.1021/jm00164a062. J Med Chem. 1990. PMID: 2299649
A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.
Fletcher DS, Osinga DG, Hand KM, Dellea PS, Ashe BM, Mumford RA, Davies P, Hagmann W, Finke PE, Doherty JB, et al. Fletcher DS, et al. Am Rev Respir Dis. 1990 Mar;141(3):672-7. doi: 10.1164/ajrccm/141.3.672. Am Rev Respir Dis. 1990. PMID: 2310097
Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase.
Doherty JB, Shah SK, Finke PE, Dorn CP Jr, Hagmann WK, Hale JJ, Kissinger AL, Thompson KR, Brause K, Chandler GO, et al. Doherty JB, et al. Among authors: hagmann wk. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8727-31. doi: 10.1073/pnas.90.18.8727. Proc Natl Acad Sci U S A. 1993. PMID: 8378355 Free PMC article.
Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage.
Olszewski JM, Moore VL, McDonnell J, Williams H, Saphos CA, Green BG, Knight WB, Chapman KT, Hagmann WK, Dorn CP, Hale JJ, Mumford RA. Olszewski JM, et al. Among authors: hagmann wk. Connect Tissue Res. 1996;33(4):291-9. doi: 10.3109/03008209609028887. Connect Tissue Res. 1996. PMID: 8834447
86 results