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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
Negoro N, Sasaki S, Mikami S, Ito M, Suzuki M, Tsujihata Y, Ito R, Harada A, Takeuchi K, Suzuki N, Miyazaki J, Santou T, Odani T, Kanzaki N, Funami M, Tanaka T, Kogame A, Matsunaga S, Yasuma T, Momose Y. Negoro N, et al. Among authors: harada a. ACS Med Chem Lett. 2010 Jun 18;1(6):290-4. doi: 10.1021/ml1000855. eCollection 2010 Sep 9. ACS Med Chem Lett. 2010. PMID: 24900210 Free PMC article.
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.
Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, Momose Y, Takeuchi K. Tsujihata Y, et al. Among authors: harada a. J Pharmacol Exp Ther. 2011 Oct;339(1):228-37. doi: 10.1124/jpet.111.183772. Epub 2011 Jul 13. J Pharmacol Exp Ther. 2011. PMID: 21752941
Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non-alcoholic steatohepatitis, modified choline-deficient, amino acid-defined diet fed low-density lipoprotein receptor knockout mice.
Tsuchiya S, Amano Y, Isono O, Imai M, Shimizu F, Asada M, Imai S, Harada A, Yasuhara Y, Tozawa R, Nagabukuro H. Tsuchiya S, et al. Among authors: harada a. Hepatol Res. 2017 May;47(6):584-592. doi: 10.1111/hepr.12773. Epub 2016 Aug 17. Hepatol Res. 2017. PMID: 27421062
Application of a laparoscopic device for cell-derived sheet transplantation on the liver in a porcine model.
Toya K, Tomimaru Y, Kobayashi S, Nakajima K, Harada A, Sasaki K, Iwagami Y, Yamada D, Noda T, Takahashi H, Hayakawa K, Matsuda I, Naka T, Miyagawa S, Doki Y, Eguchi H. Toya K, et al. Among authors: harada a. Minim Invasive Ther Allied Technol. 2024 Apr 9:1-7. doi: 10.1080/13645706.2024.2328610. Online ahead of print. Minim Invasive Ther Allied Technol. 2024. PMID: 38592474
1,397 results