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Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG. Strand ME, et al. Among authors: hasic a. FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24. FEBS J. 2013. PMID: 23374111 Free article.
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.
Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G. Finsen AV, et al. Among authors: hasic a. PLoS One. 2011;6(12):e28302. doi: 10.1371/journal.pone.0028302. Epub 2011 Dec 2. PLoS One. 2011. PMID: 22164265 Free PMC article.
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart.
Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G. Romaine A, et al. Among authors: hasic a. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H1057-H1071. doi: 10.1152/ajpheart.00635.2021. Epub 2022 May 6. Am J Physiol Heart Circ Physiol. 2022. PMID: 35522553 Free article.
19 results